e-Drug3D

1946

LEFAMULIN

INN
LEFAMULIN

cas 1061337-51-6

CLASS

ANTIINFECTIVES
PLEUROMUTILIN ANTIBACTERIAL
TREATMENT OF BACTERIAL PNEUMONIA (CABP)
INTERACTS WITH A- AND P-SITES OF THE PEPTIDYL TRANSFERASE CENTER (PTC) IN DOMAIN V OF THE 23S RRNA OF THE 50S SUBUNIT

ROUTE (list)

ORAL INTRAVENOUS

ATC code

J01XX12

PK parameters

F 25 PERCENT
Tmax 1.4 HOUR
VD 86.1 LITER
Cl 11.9 LITER / HOUR
PPB 94.8 PERCENT
t1/2 8 HOUR

Target

TARGET RIBOSOMAL SUBUNIT 50S

PDB
5HL7 (THE CRYSTAL STRUCTURE OF THE LARGE RIBOSOMAL SUBUNIT OF STAPHYLOCOCCUS AUREUS IN COMPLEX WITH LEFAMULIN)

Ligand code = 62B (link to the list of PDB complexes)

Download experimental 3D coordinates of 62B with added hydrogens

DrugCentral

Unknown

Download SDF file

Acetic acid, 2-[[(1R,2R,4R)-4-amino-2-hydroxycyclohexyl]thio]-, (3aS,4R,5S,6S,8R,9R,9aR,10R)-6-ethenyldecahydro-5-hydroxy-4,6,9,10-tetramethyl-1-oxo-3a,9-propano-3aH-cyclopentacycloocten-8-yl ester

Formula:
C28H45NO5S

Calculated chemical properties:

MW 507.72
NB_atoms 35
XLogP 3.87
PSA 97.465
NB_HD 4
NB_HA 6
fsp3 0.86
Lipinski(0=no;1=yes) 0

FDA
NDA 211672 (label) INN (LEFAMULIN ACETATE) XENLETA (HONG KONG) APPROVAL= AP YEAR= 2019 NEWMOLECULARENTITY
NDA 211673 (label) INN (LEFAMULIN ACETATE) XENLETA (HONG KONG) APPROVAL= AP YEAR= 2019