e-Drug3D

1944

TRIFAROTENE

INN
TRIFAROTENE

cas 895542-09-3

CLASS

DERMATOLOGICALS
RETINOID
TREATMENT OF ACNE VULGARIS
RETINOIC ACID RECEPTORS (RAR) AGONIST WITH PARTICULAR ACTIVITY AT THE GAMMA SUBTYPE OF RAR

ROUTE (list)

TOPICAL

ATC code

D10AD06

PK parameters

PPB 99.9 PERCENT
t1/2 5.5 HOUR

Solubility

PRACTICALLY INSOLUBLE IN WATER

Target

TARGET RETINOIC ACID RECEPTOR (RAR) GAMMA

Retinoic acid receptor gamma UNIPROT P13631 RARG

Download SDF file

[1,1':3',1''-Terphenyl]-4-carboxylic acid, 3''-(1,1-dimethylethyl)-4'-(2-hydroxyethoxy)-4''-(1-pyrrolidinyl)-

Formula:
C29H33NO4

Calculated chemical properties:

MW 458.56
NB_atoms 34
XLogP 4.65
PSA 68.398
NB_HD 1
NB_HA 5
fsp3 0.34
Lipinski(0=no;1=yes) 1

FDA
NDA 211527 (label) INN (TRIFAROTENE) AKLIEF (GALDERMA LABS LP) APPROVAL= AP YEAR= 2019 NEWMOLECULARENTITY