e-Drug3D

1942

PITOLISANT

INN
PITOLISANT

cas 362665-56-3

CLASS

NERVOUS SYSTEM
HISTAMINE-3 (H3) RECEPTOR ANTAGONIST/INVERSE AGONIST (KI = 1NM)
TREATMENT OF NARCOLEPSY

ROUTE (list)

ORAL

ATC code

N07XX11

PK parameters

F 90 PERCENT
Tmax 3.5 HOUR
VD 700 LITER
Cl 43.9 LITER / HOUR
PPB 93.5 PERCENT
t1/2 20 HOUR

Solubility

SOLUBLE IN WATER

Target

TARGET HISTAMINE-3 (H3) RECEPTOR

DrugCentral

Histamine H3 receptor UNIPROT Q9Y5N1 HRH3

Download SDF file

Piperidine, 1-[3-[3-(4-chlorophenyl)propoxy]propyl]-

Formula:
C17H26ClNO

Calculated chemical properties:

MW 295.84
NB_atoms 20
XLogP 4.17
PSA 16.001
NB_HD 0
NB_HA 2
fsp3 0.65
Lipinski(0=no;1=yes) 1

FDA
NDA 211150 (label) INN (PITOLISANT HYDROCHLORIDE) WAKIX (HARMONY) APPROVAL= AP YEAR= 2019 NEWMOLECULARENTITY
NDA 218873 (pdf not found) INN (PITOLISANT) PITOLISANT (MSN LABORATORIES PRIVATE LTD) APPROVAL= TA YEAR= 2025