e-Drug3D

1941

AFAMELANOTIDE

INN
AFAMELANOTIDE

cas 75921-69-6

CLASS

DERMATOLOGICALS
MELANOCORTIN 1 RECEPTOR (MC1-R) AGONIST
TREATMENT OF PHOTOTOXIC REACTIONS FROM ERYTHROPOIETIC PROTOPORPHYRIA (EPP)
A STRUCTURAL ANALOG OF ALPHA-MELANOCYTE STIMULATING HORMONE (ALPHA-MSH)

ROUTE (list)

SUBCUTANEOUS

ATC code

D02BB02

PK parameters

Tmax 36 HOUR
t1/2 15 HOUR

Solubility

FREELY SOLUBLE IN WATER

Target

TARGET MELANOCORTIN 1 RECEPTOR (MC1-R)

DrugCentral

Melanocyte-stimulating hormone receptor UNIPROT Q01726 MC1R

Download SDF file

alpha-Melanotropin (swine), 4-L-norleucine-7-D-phenylalanine-

Formula:
C78H111N21O19

Calculated chemical properties:

MW 1646.88
NB_atoms 118
XLogP -7.25
PSA 587.706
NB_HD 26
NB_HA 39
fsp3 0.50
Lipinski(0=no;1=yes) 0

FDA
NDA 210797 (label) INN (AFAMELANOTIDE) SCENESSE (CLIVUNEL INC) APPROVAL= AP YEAR= 2019 NEWMOLECULARENTITY