e-Drug3D

1933

LUMATEPERONE

INN
LUMATEPERONE

cas 313368-91-1

CLASS

NERVOUS SYSTEM
ANTIPSYCHOTIC INDICATED FOR THE TREATMENT OF SCHIZOPHRENIA IN ADULTS
ACTIVITY COULD BE ANTAGONISTIC ACTIVITY AT CENTRAL SEROTONIN 5-HT2A RECEPTORS (KI = 0.54 NM) AND DOPAMINE D2 RECEPTORS (KI = 32 NM)

ROUTE (list)

ORAL

ATC code

N05AD10

PK parameters

F 4.4 PERCENT
Tmax 1.5 HOUR
VD 266.5 LITER (65 KILOGRAM)
Cl 27.9 LITER / HOUR
PPB 97.4 PERCENT
t1/2 18 HOUR

Target

TARGET 5-HT2A RECEPTORS
DOPAMINE D2 RECEPTORS

PDB
7WC8 (CRYSTAL STRUCTURE OF SEROTONIN 2A RECEPTOR IN COMPLEX WITH LUMATEPERONE)

Ligand code = 92S (link to the list of PDB complexes)

Download experimental 3D coordinates of 92S with added hydrogens

DrugCentral

D(2) dopamine receptor UNIPROT P14416 DRD2

5-hydroxytryptamine receptor 2A UNIPROT P28223 HTR2A

Download SDF file

1-Butanone, 1-(4-fluorophenyl)-4-[(6bR,10aS)-2,3,6b,9,10,10a-hexahydro-3-methyl-1H-pyrido[3',4':4,5]pyrrolo[1,2,3-de]quinoxalin-8(7H)-yl]-

Formula:
C24H28FN3O

Calculated chemical properties:

MW 393.49
NB_atoms 29
XLogP 3.92
PSA 33.472
NB_HD 0
NB_HA 4
fsp3 0.46
Lipinski(0=no;1=yes) 1

FDA
NDA 209500 (pdf not found) INN (LUMATEPERONE TOSYLATE) CAPLYTA (INTRA-CELLULAR) APPROVAL= AP YEAR= 2019 NEWMOLECULARENTITY
NDA 219085 (pdf not found) INN (LUMATEPERONE) LUMATEPERONE (AUROBINDO PHARMA LIMITED) APPROVAL= TA YEAR= 2025
NDA 219142 (pdf not found) INN (LUMATEPERONE TOSYLATE) LUMATEPERONE TOSYLATE (HETERO LABS LIMITED) APPROVAL= TA YEAR= 2025
NDA 219200 (pdf not found) INN (LUMATEPERONE) LUMATEPERONE (ALKEM LABS LTD) APPROVAL= TA YEAR= 2025
NDA 219229 (pdf not found) INN (LUMATEPERONE) LUMATEPERONE (DR. REDDY'S LABORATORIES LIMITED) APPROVAL= TA YEAR= 2025
NDA 219248 (pdf not found) INN (LUMATEPERONE TOSYLATE) LUMATEPERONE TOSYLATE (MSN LABORATORIES PRIVATE LTD) APPROVAL= TA YEAR= 2025