e-Drug3D

1932

CEFIDEROCOL

INN
CEFIDEROCOL

cas 1225208-94-5

CLASS

ANTIINFECTIVES
CEPHALOSPORIN ANTIBACTERIAL
TREATMENT OF COMPLICATED URINARY TRACT INFECTIONS (CUTI)
BINDS TO EXTRACELLULAR FREE FERRIC IRON FOR A PASSIVE DIFFUSION VIA PORIN CHANNEL

ROUTE (list)

INTRAVENOUS

ATC code

J01DI04

PK parameters

VD 18 LITER
Cl 5.18 LITER / HOUR
PPB 50 PERCENT
t1/2 2.5 HOUR

Target

TARGET PENICILLIN-BINDING PROTEINS (PBPS)

DrugCentral

Peptidoglycan synthase FtsI UNIPROT P0AD68 ftsI

Penicillin-binding protein 1A UNIPROT Q07806 mrcA

Download SDF file

Pyrrolidinium, 1-[[(6R,7R)-7-[[(2Z)-2-(2-amino-4-thiazolyl)-2-[(1-carboxy-1-methylethoxy)imino]acetyl]amino]-2-carboxy-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-en-3-yl]methyl]-1-[2-[(2-chloro-3,4-dihydroxybenzoyl)amino]ethyl]-

Formula:
C30H34ClN7O10S2

Calculated chemical properties:

MW 751.22
NB_atoms 50
XLogP -1.52
PSA 220.631
NB_HD 6
NB_HA 16
fsp3 0.43
Lipinski(0=no;1=yes) 0

FDA
NDA 209445 (pdf not found) INN (CEFIDEROCOL SULFATE TOSYLATE) FETROJA (SHIONOGI INC) APPROVAL= AP YEAR= 2019 NEWMOLECULARENTITY