e-Drug3D
193
ORPHENADRINE
INN
ORPHENADRINE
cas 83-98-7
CLASS
MUSCULO-SKELETAL
SKELETAL MUSCLE RELAXANT
ANTIDYSKINETICS
ANTIPARKINSON AGENTS
MUSCARINIC ANTAGONISTS
PARASYMPATHOLYTICS
ROUTE (list)
ORAL INJECTION
PK parameters
t1/2 16.6 HOUR
Solubility
SPARINGLY SOLUBLE IN WATER
TARGET GLUTAMATE [NMDA] RECEPTOR
HISTAMINE RECEPTOR
MUSCARINIC RECEPTOR
Sodium channel protein type 5 subunit alpha UNIPROT Q14524 SCN5A
Histamine H1 receptor UNIPROT P35367 HRH1
Formula:
C18H23NO
Calculated chemical properties:
MW 269.37
NB_atoms 20
XLogP 3.66
PSA 14.58
NB_HD 0
NB_HA 2
fsp3 0.33
Lipinski(0=no;1=yes) 1
NB_atoms 20
XLogP 3.66
PSA 14.58
NB_HD 0
NB_HA 2
fsp3 0.33
Lipinski(0=no;1=yes) 1
FDA
NDA 084303 (pdf not found) INN (ORPHENADRINE CITRATE) ORPHENADRINE CITRATE (WATSON LABS) APPROVAL= - YEAR= 0 DISCONTINUED
NDA 088067 (pdf not found) INN (ORPHENADRINE CITRATE) ORPHENADRINE CITRATE (ASCOT) APPROVAL= - YEAR= 0 DISCONTINUED
NDA 010653 (pdf not found) INN (ORPHENADRINE HYDROCHLORIDE) DISIPAL (3M) APPROVAL= AP YEAR= 1957 NEWMOLECULARENTITY DISCONTINUED
NDA 012157 (pdf not found) INN (ORPHENADRINE CITRATE) NORFLEX (BAUSCH) APPROVAL= AP YEAR= 1959 DISCONTINUED
NDA 013055 (pdf not found) INN (ORPHENADRINE CITRATE) NORFLEX (PAI HOLDINGS PHARM) APPROVAL= AP YEAR= 1960 DISCONTINUED
NDA 013416 (pdf not found) INN (ASPIRIN ; CAFFEINE ; ORPHENADRINE CITRATE) NORGESIC (BAUSCH) APPROVAL= AP YEAR= 1964 DISCONTINUED
NDA 087062 (pdf not found) INN (ORPHENADRINE CITRATE) ORPHENADRINE CITRATE (WATSON LABS) APPROVAL= AP YEAR= 1981 DISCONTINUED
NDA 084779 (pdf not found) INN (ORPHENADRINE CITRATE) ORPHENADRINE CITRATE (WATSON LABS) APPROVAL= AP YEAR= 1982
NDA 085046 (pdf not found) INN (ORPHENADRINE CITRATE) ORPHENADRINE CITRATE (SANDOZ) APPROVAL= AP YEAR= 1982 DISCONTINUED
NDA 074654 (pdf not found) INN (ASPIRIN ; CAFFEINE ; ORPHENADRINE CITRATE) ORPHENADRINE CITRATE, ASPIRIN, AND CAFFEINE (SANDOZ) APPROVAL= AP YEAR= 1996 DISCONTINUED
NDA 074817 (pdf not found) INN (ASPIRIN ; CAFFEINE ; ORPHENADRINE CITRATE) INVAGESIC (SANDOZ) APPROVAL= AP YEAR= 1996 DISCONTINUED
NDA 040284 (pdf not found) INN (ORPHENADRINE CITRATE) ORPHENADRINE CITRATE (LUPIN) APPROVAL= AP YEAR= 1998
NDA 075141 (pdf not found) INN (ASPIRIN ; CAFFEINE ; ORPHENADRINE CITRATE) ORPHENGESIC (GALT PHARMS) APPROVAL= AP YEAR= 1998
NDA 040249 (pdf not found) INN (ORPHENADRINE CITRATE) ORPHENADRINE CITRATE (RISING) APPROVAL= AP YEAR= 1999
NDA 074988 (pdf not found) INN (ASPIRIN ; CAFFEINE ; ORPHENADRINE CITRATE) ORPHENADRINE CITRATE, ASPIRIN, AND CAFFEINE (STEVENS J) APPROVAL= AP YEAR= 1999 DISCONTINUED
NDA 040327 (pdf not found) INN (ORPHENADRINE CITRATE) ORPHENADRINE CITRATE (SANDOZ) APPROVAL= AP YEAR= 2000
NDA 040368 (pdf not found) INN (ORPHENADRINE CITRATE) ORPHENADRINE CITRATE (STEVENS J) APPROVAL= AP YEAR= 2000 DISCONTINUED
NDA 040463 (pdf not found) INN (ORPHENADRINE CITRATE) ORPHENADRINE CITRATE (HIKMA) APPROVAL= AP YEAR= 2003
NDA 040484 (pdf not found) INN (ORPHENADRINE CITRATE) ORPHENADRINE CITRATE (RISING) APPROVAL= AP YEAR= 2006
NDA 090585 (pdf not found) INN (ORPHENADRINE CITRATE) ORPHENADRINE CITRATE (SAGENT PHARMS) APPROVAL= AP YEAR= 2011
NDA 091158 (pdf not found) INN (ORPHENADRINE CITRATE) ORPHENADRINE CITRATE (UNICHEM) APPROVAL= AP YEAR= 2012
NDA 084303 (pdf not found) INN (ORPHENADRINE CITRATE) ORPHENADRINE CITRATE (WATSON LABS) APPROVAL= - YEAR= 0 DISCONTINUED
NDA 088067 (pdf not found) INN (ORPHENADRINE CITRATE) ORPHENADRINE CITRATE (ASCOT) APPROVAL= - YEAR= 0 DISCONTINUED
NDA 010653 (pdf not found) INN (ORPHENADRINE HYDROCHLORIDE) DISIPAL (3M) APPROVAL= AP YEAR= 1957 NEWMOLECULARENTITY DISCONTINUED
NDA 012157 (pdf not found) INN (ORPHENADRINE CITRATE) NORFLEX (BAUSCH) APPROVAL= AP YEAR= 1959 DISCONTINUED
NDA 013055 (pdf not found) INN (ORPHENADRINE CITRATE) NORFLEX (PAI HOLDINGS PHARM) APPROVAL= AP YEAR= 1960 DISCONTINUED
NDA 013416 (pdf not found) INN (ASPIRIN ; CAFFEINE ; ORPHENADRINE CITRATE) NORGESIC (BAUSCH) APPROVAL= AP YEAR= 1964 DISCONTINUED
NDA 087062 (pdf not found) INN (ORPHENADRINE CITRATE) ORPHENADRINE CITRATE (WATSON LABS) APPROVAL= AP YEAR= 1981 DISCONTINUED
NDA 084779 (pdf not found) INN (ORPHENADRINE CITRATE) ORPHENADRINE CITRATE (WATSON LABS) APPROVAL= AP YEAR= 1982
NDA 085046 (pdf not found) INN (ORPHENADRINE CITRATE) ORPHENADRINE CITRATE (SANDOZ) APPROVAL= AP YEAR= 1982 DISCONTINUED
NDA 074654 (pdf not found) INN (ASPIRIN ; CAFFEINE ; ORPHENADRINE CITRATE) ORPHENADRINE CITRATE, ASPIRIN, AND CAFFEINE (SANDOZ) APPROVAL= AP YEAR= 1996 DISCONTINUED
NDA 074817 (pdf not found) INN (ASPIRIN ; CAFFEINE ; ORPHENADRINE CITRATE) INVAGESIC (SANDOZ) APPROVAL= AP YEAR= 1996 DISCONTINUED
NDA 040284 (pdf not found) INN (ORPHENADRINE CITRATE) ORPHENADRINE CITRATE (LUPIN) APPROVAL= AP YEAR= 1998
NDA 075141 (pdf not found) INN (ASPIRIN ; CAFFEINE ; ORPHENADRINE CITRATE) ORPHENGESIC (GALT PHARMS) APPROVAL= AP YEAR= 1998
NDA 040249 (pdf not found) INN (ORPHENADRINE CITRATE) ORPHENADRINE CITRATE (RISING) APPROVAL= AP YEAR= 1999
NDA 074988 (pdf not found) INN (ASPIRIN ; CAFFEINE ; ORPHENADRINE CITRATE) ORPHENADRINE CITRATE, ASPIRIN, AND CAFFEINE (STEVENS J) APPROVAL= AP YEAR= 1999 DISCONTINUED
NDA 040327 (pdf not found) INN (ORPHENADRINE CITRATE) ORPHENADRINE CITRATE (SANDOZ) APPROVAL= AP YEAR= 2000
NDA 040368 (pdf not found) INN (ORPHENADRINE CITRATE) ORPHENADRINE CITRATE (STEVENS J) APPROVAL= AP YEAR= 2000 DISCONTINUED
NDA 040463 (pdf not found) INN (ORPHENADRINE CITRATE) ORPHENADRINE CITRATE (HIKMA) APPROVAL= AP YEAR= 2003
NDA 040484 (pdf not found) INN (ORPHENADRINE CITRATE) ORPHENADRINE CITRATE (RISING) APPROVAL= AP YEAR= 2006
NDA 090585 (pdf not found) INN (ORPHENADRINE CITRATE) ORPHENADRINE CITRATE (SAGENT PHARMS) APPROVAL= AP YEAR= 2011
NDA 091158 (pdf not found) INN (ORPHENADRINE CITRATE) ORPHENADRINE CITRATE (UNICHEM) APPROVAL= AP YEAR= 2012