e-Drug3D

1921

DUVELISIB

INN
DUVELISIB

cas 1201438-56-3

CLASS

ANTINEOPLASTIC
PI3K DELTA AND PI3K GAMMA KINASE INHIBITOR
TREATMENT OF REFRACTORY CHRONIC LYMPHOCYTIC LEUKEMIA (CLL)

ROUTE (list)

ORAL

ATC code

L01EM04

PK parameters

F 42 PERCENT
Tmax 1.5 HOUR
VD 28.5 LITER
Cl 4.2 LITER / HOUR
PPB 98 PERCENT
t1/2 4.7 HOUR

Solubility

PRACTICALLY INSOLUBLE IN WATER

Target

TARGET PI3K

Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform UNIPROT O00329 PIK3CD

Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform UNIPROT P48736 PIK3CG

Download SDF file

1(2H)-Isoquinolinone, 8-chloro-2-phenyl-3-[(1S)-1-(9H-purin-6-ylamino)ethyl]-

Formula:
C22H17ClN6O

Calculated chemical properties:

MW 416.87
NB_atoms 30
XLogP 4.48
PSA 59.574
NB_HD 2
NB_HA 7
fsp3 0.09
Lipinski(0=no;1=yes) 1

FDA
NDA 211155 (label) INN (DUVELISIB) COPIKTRA (SECURA) APPROVAL= AP YEAR= 2018 NEWMOLECULARENTITY