e-Drug3D

1918

RIFAMYCIN

DISCONTINUED

INN
RIFAMYCIN

cas 6998-60-3

CLASS

ANTIINFECTIVES
TREATMENT OF TRAVELERS DIARRHEA CAUSED BY NONINVASIVE STRAINS OF ESCHERICHIA COLI
ANSAMYCIN CLASS OF ANTIBACTERIAL DRUGS

ROUTE (list)

ORAL

PK parameters

F 0.1 PERCENT
Tmax 6 HOUR
PPB 80 PERCENT

Solubility

SOLUBLE IN WATER

Target

TARGET BETA-SUBUNIT DNA-DEPENDENT RNA POLYMERASE

PDB
6BEB (CRYSTAL STRUCTURE OF VACV D13)

Download experimental 3D coordinates of RFV with added hydrogens

DNA-directed RNA polymerase subunit beta UNIPROT P0A8V2 rpoB

Download SDF file

Rifamycin (9CI)

Formula:
C37H47NO12

Calculated chemical properties:

MW 697.76
NB_atoms 50
XLogP 4.75
PSA 177.628
NB_HD 6
NB_HA 13
fsp3 0.49
Lipinski(0=no;1=yes) 0

FDA
NDA 210910 (label) INN (RIFAMYCIN SODIUM) AEMCOLO (COSMO TECHNOLOGIES) APPROVAL= AP YEAR= 2018 NEWMOLECULARENTITY DISCONTINUED