e-Drug3D

1916

MOXIDECTIN

INN
MOXIDECTIN

cas 113507-06-5

CLASS

ANTIPARASITIC
ANTHELMINTIC
TREATMENT OF ONCHOCERCIASIS
MACROCYCLIC LACTONE
MILBEMYCIN

ROUTE (list)

ORAL

ATC code

P02CX03

PK parameters

Tmax 4 HOUR
VD 2421 LITER
Cl 3.5 LITER / HOUR
t1/2 784 HOUR

Solubility

SLIGHTLY SOLUBLE IN WATER (0.51 MILLIGRAM PER LITER)

Target

TARGET GLUTAMATE-GATED CHLORIDE CHANNELS (GLUCL)

Glutamate-gated chloride channel UNIPROT Q25634 GluClX

Download SDF file

Milbemycin B, 5-O-demethyl-28-deoxy-25-[(1E)-1,3-dimethyl-1-buten-1-yl]-6,28-epoxy-23-(methoxyimino)-, (6R,23E,25S)-

Formula:
C37H53NO8

Calculated chemical properties:

MW 639.80
NB_atoms 46
XLogP 5.73
PSA 105.014
NB_HD 2
NB_HA 9
fsp3 0.68
Lipinski(0=no;1=yes) 0

FDA
NDA 210867 (label) INN (MOXIDECTIN) MOXIDECTIN (MDGH) APPROVAL= AP YEAR= 2018 NEWMOLECULARENTITY