e-Drug3D

1913

BALOXAVIR MARBOXIL

INN
BALOXAVIR MARBOXIL

(has an active metabolite)

cas 1985606-14-1

CLASS

ANTIINFECTIVES
PRODRUG
POLYMERASE ACIDIC (PA) ENDONUCLEASE INHIBITOR
TREATMENT OF ACUTE UNCOMPLICATED INFLUENZA

ROUTE (list)

ORAL

ATC code

J05AX25

PK parameters

Solubility

PRACTICALLY INSOLUBLE IN WATER

Target

TARGET POLYMERASE ACIDIC PROTEIN

DrugCentral

Polymerase acidic protein UNIPROT P03433 PA

Download SDF file

Carbonic acid, [[(12aR)-12-[(11S)-7,8-difluoro-6,11-dihydrodibenzo[b,e]thiepin-11-yl]-3,4,6,8,12,12a-hexahydro-6,8-dioxo-1H-[1,4]oxazino[3,4-c]pyrido[2,1-f][1,2,4]triazin-7-yl]oxy]methyl methyl ester

Formula:
C27H23F2N3O7S

Calculated chemical properties:

MW 571.55
NB_atoms 40
XLogP 3.39
PSA 96.3
NB_HD 0
NB_HA 10
fsp3 0.30
Lipinski(0=no;1=yes) 0

FDA
NDA 210854 (label) INN (BALOXAVIR MARBOXIL) XOFLUZA (GENENTECH INC) APPROVAL= AP YEAR= 2018 NEWMOLECULARENTITY
NDA 214410 (label) INN (BALOXAVIR MARBOXIL) XOFLUZA (GENENTECH INC) APPROVAL= AP YEAR= 2020