e-Drug3D

1911

GLASDEGIB

INN
GLASDEGIB

cas 1095173-27-5

CLASS

ANTINEOPLASTIC
INHIBITOR OF THE HEDGEHOG PATHWAY
INHIBITS SMOOTHENED TRANSMEMBRANE PROTEIN (SMO)
TREATMENT OF ACUTE MYELOID LEUKEMIA (AML)

ROUTE (list)

ORAL

ATC code

L01XJ03

PK parameters

F 77 PERCENT
Tmax 1.55 HOUR
VD 188 LITER
Cl 6.45 LITER / HOUR
PPB 91 PERCENT
t1/2 17.4 HOUR

Solubility

SOLUBLE IN WATER (1.7 MILLIGRAM PER MILLIMITER)

Target

TARGET SMOOTHENED (SMO)

Smoothened homolog UNIPROT Q99835 SMO

Download SDF file

Urea, N-[(2R,4R)-2-(1H-benzimidazol-2-yl)-1-methyl-4-piperidinyl]-N'-(4-cyanophenyl)-

Formula:
C21H22N6O

Calculated chemical properties:

MW 374.45
NB_atoms 28
XLogP 3.39
PSA 87.064
NB_HD 3
NB_HA 7
fsp3 0.29
Lipinski(0=no;1=yes) 1

FDA
NDA 210656 (label) INN (GLASDEGIB MALEATE) DAURISMO (PFIZER) APPROVAL= AP YEAR= 2018 NEWMOLECULARENTITY