e-Drug3D

1898

PLAZOMICIN

INN
PLAZOMICIN

cas 1154757-24-0

CLASS

ANTIINFECTIVES
AMINOGLYCOSIDE ANTIBACTERIAL DERIVED FROM SISOMICIN
TREATMENT OF COMPLICATED URINARY TRACT INFECTIONS (CUTI) INCLUDING PYELONEPHRITIS

ROUTE (list)

INTRAVENOUS

ATC code

J01GB14

PK parameters

VD 17.9 LITER
Cl 4.5 LITER / HOUR
PPB 20 PERCENT
t1/2 3.5 HOUR

Target

TARGET 30S RIBOSOMAL SUBUNIT

PDB
6CD7 (CRYSTAL STRUCTURE OF APH(2)-IVA)

Ligand code = EDS (link to the list of PDB complexes)

Download experimental 3D coordinates of EDS with added hydrogens

DrugCentral

Unknown

Download SDF file

D-Streptamine, O-2-amino-2,3,4,6-tetradeoxy-6-[(2-hydroxyethyl)amino]-alpha-D-glycero-hex-4-enopyranosyl-(1->4)-O-[3-deoxy-4-C-methyl-3-(methylamino)-beta-L-arabinopyranosyl-(1->6)]-N1-[(2S)-4-amino-2-hydroxy-1-oxobutyl]-2-deoxy-

Formula:
C25H48N6O10

Calculated chemical properties:

MW 592.69
NB_atoms 41
XLogP -5.36
PSA 262.677
NB_HD 14
NB_HA 16
fsp3 0.88
Lipinski(0=no;1=yes) 0

FDA
NDA 210303 (label) INN (PLAZOMICIN SULFATE) ZEMDRI (CIPLA USA) APPROVAL= AP YEAR= 2018 NEWMOLECULARENTITY