e-Drug3D
1896
SIPONIMOD
INN
SIPONIMOD
cas 1230487-00-9
CLASS
IMMUNOSUPPRESSANTS
A SPHINGOSINE 1-PHOSPHATE RECEPTOR MODULATOR (SIP RECEPTORS 1 AND 5)
TREATMENT OF RELAPSING FORMS OF MULTIPLE SCLEROSIS (MS)
REDUCES THE NUMBER OF LYMPHOCYTES IN PERIPHERAL BLOOD
ROUTE (list)
ORAL
ATC code
L04AE03
PK parameters
F 84 PERCENT
Tmax 4 HOUR
VD 124 LITER
Cl 3.11 LITER / HOUR
PPB 99.9 PERCENT
t1/2 30 HOUR
TARGET SPHINGOSINE 1-PHOSPHATE RECEPTOR (S1P)
PDB
7EVY (CRYO-EM STRUCTURE OF SIPONIMOD -BOUND SPHINGOSINE-1-PHOSPHATE RECEPTOR 1 IN COMPLEX WITH GI PROTEIN)
Ligand code = J8C (link to the list of PDB complexes)
Download experimental 3D coordinates of J8C with added hydrogens
Sphingosine 1-phosphate receptor 1 UNIPROT P21453 S1PR1
Sphingosine 1-phosphate receptor 5 UNIPROT Q9H228 S1PR5
Formula:
C29H35F3N2O3
Calculated chemical properties:
MW 515.58
NB_atoms 37
XLogP 5.44
PSA 62.152
NB_HD 0
NB_HA 5
fsp3 0.52
Lipinski(0=no;1=yes) 0
NB_atoms 37
XLogP 5.44
PSA 62.152
NB_HD 0
NB_HA 5
fsp3 0.52
Lipinski(0=no;1=yes) 0
FDA
NDA 209884 (label) INN (SIPONIMOD) MAYZENT (NOVARTIS) APPROVAL= AP YEAR= 2019 NEWMOLECULARENTITY
NDA 218228 (pdf not found) INN (SIPONIMOD) SIPONIMOD (CIPLA LTD) APPROVAL= TA YEAR= 2025
NDA 218393 (pdf not found) INN (SIPONIMOD) SIPONIMOD (DR REDDYS LABS LTD) APPROVAL= TA YEAR= 2025
NDA 218444 (pdf not found) INN (SIPONIMOD) SIPONIMOD (RICONPHARMA LLC) APPROVAL= AP YEAR= 2025 DISCONTINUED
NDA 209884 (label) INN (SIPONIMOD) MAYZENT (NOVARTIS) APPROVAL= AP YEAR= 2019 NEWMOLECULARENTITY
NDA 218228 (pdf not found) INN (SIPONIMOD) SIPONIMOD (CIPLA LTD) APPROVAL= TA YEAR= 2025
NDA 218393 (pdf not found) INN (SIPONIMOD) SIPONIMOD (DR REDDYS LABS LTD) APPROVAL= TA YEAR= 2025
NDA 218444 (pdf not found) INN (SIPONIMOD) SIPONIMOD (RICONPHARMA LLC) APPROVAL= AP YEAR= 2025 DISCONTINUED