e-Drug3D

1890

TRICLABENDAZOLE

INN
TRICLABENDAZOLE

cas 68786-66-3

CLASS

ANTIPARASITIC
ANTHELMINTIC
TREATMENT OF FASCIOLIASIS
TRICLABENDAZOLE AND ITS METABOLITES ARE ACTIVE AGAINST THE IMMATURE AND MATURE WORMS

ROUTE (list)

ORAL

ATC code

P02BX04

PK parameters

Tmax 3.5 HOUR
PPB 96.7 PERCENT
t1/2 8 HOUR

Target

PDB
7ERI (CRYSTAL STRUCTURE OF V30M-TTR IN COMPLEX WITH TRICLABENDAZOLE)

Download experimental 3D coordinates of JA9 with added hydrogens

Unknown

Download SDF file

1H-Benzimidazole, 6-chloro-5-(2,3-dichlorophenoxy)-2-(methylthio)-

Formula:
C14H9Cl3N2OS

Calculated chemical properties:

MW 359.65
NB_atoms 21
XLogP 6.04
PSA 34.693
NB_HD 1
NB_HA 3
fsp3 0.07
Lipinski(0=no;1=yes) 0

FDA
NDA 208711 (label) INN (TRICLABENDAZOLE) EGATEN (NOVARTIS) APPROVAL= AP YEAR= 2019 NEWMOLECULARENTITY