e-Drug3D

1889

TECOVIRIMAT

INN
TECOVIRIMAT

cas 869572-92-9

CLASS

ANTIINFECTIVES
ANTIVIRAL AGAINST VARIOLA
TREATMENT OF HUMAN SMALLPOX DISEASE
INHIBITOR OF THE ORTHOPOXVIRUS VP37 ENVELOPE
BLOCKS ITS INTERACTION WITH CELLULAR RAB9 GTPASE AND TIP47

ROUTE (list)

ORAL INTRAVENOUS

ATC code

J05AX24

PK parameters

Tmax 5 HOUR
VD 1030 LITER
Cl 31 LITER / HOUR
PPB 79 PERCENT
t1/2 20 HOUR

Solubility

PRACTICALLY INSOLUBLE IN WATER

Target

TARGET VP37 PROTEIN

DrugCentral

Envelope protein F13 UNIPROT P33815 C17L

Download SDF file

Benzamide, N-[(3aR,4R,4aR,5aS,6S,6aS)-3,3a,4,4a,5,5a,6,6a-octahydro-1,3-dioxo-4,6-ethenocycloprop[f]isoindol-2(1H)-yl]-4-(trifluoromethyl)-, rel-

Formula:
C19H15F3N2O3

Calculated chemical properties:

MW 376.33
NB_atoms 27
XLogP 2.40
PSA 66.11
NB_HD 1
NB_HA 5
fsp3 0.42
Lipinski(0=no;1=yes) 1

FDA
NDA 208627 (pdf not found) INN (TECOVIRIMAT) TPOXX (SIGA TECHNOLOGIES) APPROVAL= AP YEAR= 2018 NEWMOLECULARENTITY
NDA 214518 (pdf not found) INN (TECOVIRIMAT) TPOXX (SIGA TECHNOLOGIES) APPROVAL= AP YEAR= 2022