e-Drug3D

1888

MIGALASTAT

INN
MIGALASTAT

cas 108147-54-2

CLASS

METABOLISM
AN ALPHA-GALACTOSIDASE A (ALPHA-GAL A) PHARMACOLOGICAL CHAPERONE
TREATMENT OF FABRY DISEASE
ANALOGUE OF THE TERMINAL GALACTOSE OF GLOBOTRIAOSYLCERAMIDE (GL-3)

ROUTE (list)

ORAL

ATC code

A16AX14

PK parameters

F 75 PERCENT
Tmax 3 HOUR
VD 89 LITER
Cl 12.5 LITER / HOUR
PPB 0 PERCENT
t1/2 4 HOUR

Solubility

FREELY SOLUBLE IN AQUEOUS MEDIA WITHIN THE PH RANGE OF 1.2 TO 7.5

Target

TARGET ALPHA-GALACTOSIDASE A

PDB
4D1J (THE STRUCTURE OF THE GH35 BETA-GALACTOSIDASE BGL35A FROM CELLVIBRIO JAPONICAS IN COMPLEX WITH 1-DEOXYGALACTONOJIRIMYCIN)

Ligand code = DGJ (link to the list of PDB complexes)

Download experimental 3D coordinates of DGJ with added hydrogens

DrugCentral

Alpha-galactosidase A UNIPROT P06280 GLA

Download SDF file

3,4,5-Piperidinetriol, 2-(hydroxymethyl)-, (2R,3S,4R,5S)-

Formula:
C6H13NO4

Calculated chemical properties:

MW 163.17
NB_atoms 11
XLogP -2.97
PSA 95.23
NB_HD 5
NB_HA 5
fsp3 1.00
Lipinski(0=no;1=yes) 1

FDA
NDA 208623 (label) INN (MIGALASTAT HYDROCHLORIDE) GALAFOLD (AMICUS THERAP US) APPROVAL= AP YEAR= 2018