e-Drug3D

1887

AMIFAMPRIDINE

INN
AMIFAMPRIDINE

cas 54-96-6

CLASS

NERVOUS SYSTEM
TREATMENT OF LAMBERT-EATON MYASTHENIC SYNDROME (LEMS)
BROAD SPECTRUM VOLTAGE-GATED POTASSIUM CHANNEL BLOCKER
THE MECHANISM OF ACTION HAS NOT BEEN FULLY ELUCIDATED

ROUTE (list)

ORAL

ATC code

N07XX05

PK parameters

Tmax 1.3 HOUR
Cl 181 LITER / HOUR
PPB 25.3 PERCENT
t1/2 2.15 HOUR

Solubility

FREELY SOLUBLE IN WATER

Target

TARGET POTASSIUM CHANNELS

PDB
5NOW (STRUCTURE OF CYCLOPHILIN A IN COMPLEX WITH PYRIDINE-3,4-DIAMINE)

Ligand code = L89 (link to the list of PDB complexes)

Download experimental 3D coordinates of L89 with added hydrogens

DrugCentral

Voltage-gated potassium channel UNIPROT O43525 KCNQ3

Download SDF file

3,4-Pyridinediamine

Formula:
C5H7N3

Calculated chemical properties:

MW 109.14
NB_atoms 8
XLogP 0.25
PSA 56.599
NB_HD 4
NB_HA 3
fsp3 0.00
Lipinski(0=no;1=yes) 1

FDA
NDA 208078 (label) INN (AMIFAMPRIDINE PHOSPHATE) FIRDAPSE (CATALYST PHARMS) APPROVAL= AP YEAR= 2018 NEWMOLECULARENTITY
NDA 209321 (label) INN (AMIFAMPRIDINE) RUZURGI (JACOBUS PHARM CO INC) APPROVAL= TA YEAR= 2019