e-Drug3D

1882

FOSNETUPITANT

INN
FOSNETUPITANT

cas 1703748-89-3

CLASS

NERVOUS SYSTEM
PRODRUG OF NETUPITANT
A SUBSTANCE P/NEUROKININ 1 (NK1) RECEPTOR ANTAGONIST
PREVENTION OF ACUTE AND DELAYED NAUSEA AND VOMITING ASSOCIATED WITH CANCER CHEMOTHERAPY

ROUTE (list)

INTRAVENOUS

ATC code

PK parameters

Tmax 0.5 HOUR
VD 124 LITER
Cl 90 LITER / HOUR
PPB 92 PERCENT
t1/2 0.96 HOUR

Solubility

IS PH DEPENDENT 11.5 MILLIGRAM PER MILLILITER AT PH 10 AND 1.4 MILLIGRAM PER MILLILITER PH 2

Target

DrugCentral

Substance-P receptor UNIPROT P25103 TACR1

Download SDF file

Piperazinium, 4-[5-[[2-[3,5-bis(trifluoromethyl)phenyl]-2-methyl-1-oxopropyl]methylamino]-4-(2-methylphenyl)-2-pyridinyl]-1-methyl-1-[(phosphonooxy)methyl]-

Formula:
C31H36F6N4O5P

Calculated chemical properties:

MW 687.59
NB_atoms 47
XLogP 5.10
PSA 95.933
NB_HD 0
NB_HA 8
fsp3 0.42
Lipinski(0=no;1=yes) 0

FDA
NDA 210493 (label) INN (FOSNETUPITANT CHLORIDE HYDROCHLORIDE ; PALONOSETRON HYDROCHLORIDE) AKYNZEO (HELSINN HLTHCARE) APPROVAL= AP YEAR= 2018