e-Drug3D
1870
SECNIDAZOLE
INN
SECNIDAZOLE
cas 3366-95-8
CLASS
ANTIPARASITIC
A NITROIMIDAZOLE ANTIMICROBIAL
TREATMENT OF BACTERIAL VAGINOSIS IN ADULT WOMEN
5-NITROIMIDAZOLES ENTER THE BACTERIAL CELL AS AN INACTIVE PRODRUG WHERE THE NITRO GROUP IS REDUCED BY BACTERIAL ENZYMES TO RADICAL ANIONS. IT IS BELIEVED THAT THESE RADICAL ANIONS INTERFERE WITH BACTERIAL DNA SYNTHESIS OF SUSCEPTIBLE ISOLATES
ROUTE (list)
ORAL
PK parameters
Tmax 4 HOUR
VD 42 LITER
Cl 1.5 LITER / HOUR
PPB 5 PERCENT
t1/2 17 HOUR
TARGET DNA
Unknown
Formula:
C7H11N3O3
Calculated chemical properties:
MW 185.19
NB_atoms 13
XLogP 0.48
PSA 75.623
NB_HD 1
NB_HA 5
fsp3 0.57
Lipinski(0=no;1=yes) 1
NB_atoms 13
XLogP 0.48
PSA 75.623
NB_HD 1
NB_HA 5
fsp3 0.57
Lipinski(0=no;1=yes) 1