e-Drug3D

1868

M FOSTAMATINIB

INN
FOSTAMATINIB

cas 841290-80-0

CLASS

ANTINEOPLASTIC
TYROSINE KINASE SYK INHIBITOR
INDICATED FOR THE TREATMENT OF THROMBOCYTOPENIA IN ADULT PATIENTS WITH CHRONIC IMMUNE THROMBOCYTOPENIA
METABOLIZED IN THE GUT BY ALKALINE PHOSPHATASE

ROUTE (list)

ATC code

B02BX09

PK parameters

F 55 PERCENT
Tmax 1.5 HOUR
VD 256 LITER
PPB 98.3 PERCENT
t1/2 15 HOUR

Target

TARGET TYROSINE KINASE SYK

PDB
3FQS (CRYSTAL STRUCTURE OF SPLEEN TYROSINE KINASE COMPLEXED WITH R406)

Ligand code = 585 (link to the list of PDB complexes)

Download experimental 3D coordinates of 585 with added hydrogens

DrugCentral

Tyrosine-protein kinase SYK UNIPROT P43405 SYK

Download SDF file

2H-Pyrido[3,2-b]-1,4-oxazin-3(4H)-one, 6-[[5-fluoro-2-[(3,4,5-trimethoxyphenyl)amino]-4-pyrimidinyl]amino]-2,2-dimethyl-

Formula:
C22H23FN6O5

Calculated chemical properties:

MW 470.46
NB_atoms 34
XLogP 3.63
PSA 122.911
NB_HD 3
NB_HA 11
fsp3 0.27
Lipinski(0=no;1=yes) 0

FDA
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