e-Drug3D

1853

cas 68538-85-2

CLASS

VARIOUS
ANTIANEMIC
ANTIDOTE TO FOLIC ACID ANTAGONISTS
ANTINEOPLASTIC ADJUNCTS
RESCUE AFTER HIGH-DOSE METHOTREXATE THERAPY IN OSTEOSARCOMA
USE IN COMBINATION CHEMOTHERAPY WITH 5-FLUOROURACIL
RAPIDLY ABSORBED AND ENTERS THE GENERAL BODY POOL OF REDUCED FOLATES
CONVERTED TO 5-METHYLTETRAHYDROFOLIC ACID (5-METHYL-THF)

ROUTE (list)

INTRAMUSCULAR INTRAVENOUS INJECTION ORAL

PK parameters

VD 16.2 LITER (65 KILOGRAM)
Cl 22.6 LITER / HOUR (65 KILOGRAM)
PPB 91 PERCENT
t1/2 1.3 HOUR

-

PDB
3UWL (CRYSTAL STRUCTURE OF ENTEROCCOCUS FAECALIS THYMIDYLATE SYNTHASE (EFTS) IN COMPLEX WITH 5-FORMYL TETRAHYDROFOLATE)

Ligand code = FOZ (link to the list of PDB complexes)

Download experimental 3D coordinates of FOZ with added hydrogens

MW 471.44
NB_atoms 34
XLogP -3.40
PSA 203.107
NB_HD 6
NB_HA 14
fsp3 0.30
Lipinski(0=no;1=yes) 0

FDA
NDA 018342 (pdf not found) INN (LEUCOVORIN CALCIUM) WELLCOVORIN (GLAXOSMITHKLINE) APPROVAL= - YEAR= 0 DISCONTINUED
NDA 071598 (pdf not found) INN (LEUCOVORIN CALCIUM) LEUCOVORIN CALCIUM (PAR PHARM) APPROVAL= - YEAR= 0 DISCONTINUED
NDA 071600 (pdf not found) INN (LEUCOVORIN CALCIUM) LEUCOVORIN CALCIUM (PAR PHARM) APPROVAL= - YEAR= 0 DISCONTINUED
NDA 087439 (pdf not found) INN (LEUCOVORIN CALCIUM) WELLCOVORIN (GLAXOSMITHKLINE) APPROVAL= - YEAR= 0 DISCONTINUED
NDA 088939 (pdf not found) INN (LEUCOVORIN CALCIUM) LEUCOVORIN CALCIUM (ABRAXIS PHARM) APPROVAL= - YEAR= 0 DISCONTINUED
NDA 089352 (pdf not found) INN (LEUCOVORIN CALCIUM) LEUCOVORIN CALCIUM (ABIC) APPROVAL= - YEAR= 0 DISCONTINUED
NDA 089353 (pdf not found) INN (LEUCOVORIN CALCIUM) LEUCOVORIN CALCIUM (ABIC) APPROVAL= - YEAR= 0 DISCONTINUED
NDA 089465 (pdf not found) INN (LEUCOVORIN CALCIUM) WELLCOVORIN (GLAXOSMITHKLINE) APPROVAL= - YEAR= 0 DISCONTINUED
NDA 089496 (pdf not found) INN (LEUCOVORIN CALCIUM) LEUCOVORIN CALCIUM (QUAD PHARMS) APPROVAL= - YEAR= 0 DISCONTINUED
NDA 089503 (pdf not found) INN (LEUCOVORIN CALCIUM) LEUCOVORIN CALCIUM (QUAD PHARMS) APPROVAL= - YEAR= 0 DISCONTINUED
NDA 089504 (pdf not found) INN (LEUCOVORIN CALCIUM) LEUCOVORIN CALCIUM (QUAD PHARMS) APPROVAL= - YEAR= 0 DISCONTINUED
NDA 089636 (pdf not found) INN (LEUCOVORIN CALCIUM) LEUCOVORIN CALCIUM (QUAD PHARMS) APPROVAL= - YEAR= 0 DISCONTINUED
NDA 089833 (pdf not found) INN (LEUCOVORIN CALCIUM) WELLCOVORIN (GLAXOSMITHKLINE) APPROVAL= - YEAR= 0 DISCONTINUED
NDA 089834 (pdf not found) INN (LEUCOVORIN CALCIUM) WELLCOVORIN (GLAXOSMITHKLINE) APPROVAL= - YEAR= 0 DISCONTINUED
NDA 008107 (label) INN (LEUCOVORIN CALCIUM) LEUCOVORIN CALCIUM (HOSPIRA) APPROVAL= AP YEAR= 1952 NEWMOLECULARENTITY DISCONTINUED
NDA 018459 (pdf not found) INN (LEUCOVORIN CALCIUM) LEUCOVORIN CALCIUM (XANODYNE PHARM) APPROVAL= AP YEAR= 1980 DISCONTINUED
NDA 070480 (pdf not found) INN (LEUCOVORIN CALCIUM) LEUCOVORIN CALCIUM (ELKINS SINN) APPROVAL= AP YEAR= 1987 DISCONTINUED
NDA 071104 (pdf not found) INN (LEUCOVORIN CALCIUM) LEUCOVORIN CALCIUM (XANODYNE PHARM) APPROVAL= AP YEAR= 1987 DISCONTINUED
NDA 071198 (pdf not found) INN (LEUCOVORIN CALCIUM) LEUCOVORIN CALCIUM (BARR) APPROVAL= AP YEAR= 1987
NDA 071199 (pdf not found) INN (LEUCOVORIN CALCIUM) LEUCOVORIN CALCIUM (BARR) APPROVAL= AP YEAR= 1987
NDA 071962 (pdf not found) INN (LEUCOVORIN CALCIUM) LEUCOVORIN CALCIUM (XANODYNE PHARM) APPROVAL= AP YEAR= 1987 DISCONTINUED
NDA 089384 (label) INN (LEUCOVORIN CALCIUM) LEUCOVORIN CALCIUM (WEST-WARD PHARMS INT) APPROVAL= AP YEAR= 1987
NDA 089717 (label) INN (LEUCOVORIN CALCIUM) LEUCOVORIN CALCIUM (WEST-WARD PHARMS INT) APPROVAL= AP YEAR= 1988
NDA 072733 (pdf not found) INN (LEUCOVORIN CALCIUM) LEUCOVORIN CALCIUM (HIKMA) APPROVAL= AP YEAR= 1993
NDA 072734 (pdf not found) INN (LEUCOVORIN CALCIUM) LEUCOVORIN CALCIUM (HIKMA) APPROVAL= AP YEAR= 1993
NDA 072735 (pdf not found) INN (LEUCOVORIN CALCIUM) LEUCOVORIN CALCIUM (HIKMA) APPROVAL= AP YEAR= 1993
NDA 072736 (pdf not found) INN (LEUCOVORIN CALCIUM) LEUCOVORIN CALCIUM (HIKMA) APPROVAL= AP YEAR= 1993
NDA 081277 (pdf not found) INN (LEUCOVORIN CALCIUM) LEUCOVORIN CALCIUM (TEVA PHARMS USA) APPROVAL= AP YEAR= 1993
NDA 081278 (pdf not found) INN (LEUCOVORIN CALCIUM) LEUCOVORIN CALCIUM (TEVA PARENTERAL) APPROVAL= AP YEAR= 1993 DISCONTINUED
NDA 081224 (pdf not found) INN (LEUCOVORIN CALCIUM) LEUCOVORIN CALCIUM (ELKINS SINN) APPROVAL= AP YEAR= 1994 DISCONTINUED
NDA 040056 (label) INN (LEUCOVORIN CALCIUM) LEUCOVORIN CALCIUM PRESERVATIVE FREE (WEST-WARD PHARMS INT) APPROVAL= AP YEAR= 1995
NDA 040147 (pdf not found) INN (LEUCOVORIN CALCIUM) LEUCOVORIN CALCIUM PRESERVATIVE FREE (HOSPIRA) APPROVAL= AP YEAR= 1997 DISCONTINUED
NDA 040174 (pdf not found) INN (LEUCOVORIN CALCIUM) LEUCOVORIN CALCIUM (TEVA PHARMS USA) APPROVAL= AP YEAR= 1997
NDA 073099 (pdf not found) INN (LEUCOVORIN CALCIUM) LEUCOVORIN CALCIUM (PHARMACHEMIE) APPROVAL= AP YEAR= 1997 DISCONTINUED
NDA 073101 (pdf not found) INN (LEUCOVORIN CALCIUM) LEUCOVORIN CALCIUM (PHARMACHEMIE) APPROVAL= AP YEAR= 1997 DISCONTINUED
NDA 074544 (pdf not found) INN (LEUCOVORIN CALCIUM) LEUCOVORIN CALCIUM (EPIC PHARMA LLC) APPROVAL= AP YEAR= 1997
NDA 089628 (pdf not found) INN (LEUCOVORIN CALCIUM) LEUCOVORIN CALCIUM (PHARMACHEMIE USA) APPROVAL= AP YEAR= 1997 DISCONTINUED
NDA 089915 (pdf not found) INN (LEUCOVORIN CALCIUM) LEUCOVORIN CALCIUM (PHARMACHEMIE USA) APPROVAL= AP YEAR= 1997 DISCONTINUED
NDA 040258 (pdf not found) INN (LEUCOVORIN CALCIUM) LEUCOVORIN CALCIUM PRESERVATIVE FREE (FRESENIUS KABI USA) APPROVAL= AP YEAR= 1999
NDA 040262 (label) INN (LEUCOVORIN CALCIUM) LEUCOVORIN CALCIUM (PHARMACHEMIE) APPROVAL= AP YEAR= 1999 DISCONTINUED
NDA 040286 (pdf not found) INN (LEUCOVORIN CALCIUM) LEUCOVORIN CALCIUM PRESERVATIVE FREE (FRESENIUS KABI USA) APPROVAL= AP YEAR= 1999
NDA 040332 (pdf not found) INN (LEUCOVORIN CALCIUM) LEUCOVORIN CALCIUM PRESERVATIVE FREE (TEVA PARENTERAL) APPROVAL= AP YEAR= 1999 DISCONTINUED
NDA 075327 (pdf not found) INN (LEUCOVORIN CALCIUM) LEUCOVORIN CALCIUM (ANI PHARMS INC) APPROVAL= AP YEAR= 1999 DISCONTINUED
NDA 040335 (label) INN (LEUCOVORIN CALCIUM) LEUCOVORIN CALCIUM PRESERVATIVE FREE (WEST-WARD PHARMS INT) APPROVAL= AP YEAR= 2000
NDA 040347 (label) INN (LEUCOVORIN CALCIUM) LEUCOVORIN CALCIUM PRESERVATIVE FREE (WEST-WARD PHARMS INT) APPROVAL= AP YEAR= 2000
NDA 040338 (pdf not found) INN (LEUCOVORIN CALCIUM) LEUCOVORIN CALCIUM PRESERVATIVE FREE (AM REGENT) APPROVAL= AP YEAR= 2001 DISCONTINUED
NDA 020140 (label) INN (LEVOLEUCOVORIN CALCIUM) FUSILEV (ACROTECH BIOPHARMA) APPROVAL= AP YEAR= 2008 DISCONTINUED
NDA 200753 (pdf not found) INN (LEUCOVORIN CALCIUM) LEUCOVORIN CALCIUM PRESERVATIVE FREE (SAGENT PHARMS) APPROVAL= AP YEAR= 2012
NDA 200855 (pdf not found) INN (LEUCOVORIN CALCIUM) LEUCOVORIN CALCIUM PRESERVATIVE FREE (SAGENT PHARMS) APPROVAL= AP YEAR= 2012
NDA 203563 (label) INN (LEVOLEUCOVORIN CALCIUM) LEVOLEUCOVORIN CALCIUM (SANDOZ) APPROVAL= AP YEAR= 2015
NDA 203576 (pdf not found) INN (LEVOLEUCOVORIN CALCIUM) LEVOLEUCOVORIN CALCIUM (NORVIUM BIOSCIENCE) APPROVAL= AP YEAR= 2015 DISCONTINUED
NDA 206263 (label) INN (LEVOLEUCOVORIN CALCIUM) LEVOLEUCOVORIN CALCIUM (HIKMA) APPROVAL= AP YEAR= 2016 DISCONTINUED
NDA 208723 (label) INN (LEVOLEUCOVORIN CALCIUM) LEVOLEUCOVORIN CALCIUM (ACTAVIS LLC) APPROVAL= AP YEAR= 2016 DISCONTINUED
NDA 207547 (pdf not found) INN (LEVOLEUCOVORIN CALCIUM) LEVOLEUCOVORIN CALCIUM (AMNEAL) APPROVAL= AP YEAR= 2017 DISCONTINUED
NDA 203800 (pdf not found) INN (LEUCOVORIN CALCIUM) LEUCOVORIN CALCIUM PRESERVATIVE FREE (MYLAN LABS LTD) APPROVAL= AP YEAR= 2017
NDA 206516 (pdf not found) INN (LEVOLEUCOVORIN CALCIUM) LEVOLEUCOVORIN CALCIUM (ACTAVIS LLC) APPROVAL= AP YEAR= 2017 DISCONTINUED
NDA 209110 (pdf not found) INN (LEUCOVORIN CALCIUM) LEUCOVORIN CALCIUM PRESERVATIVE FREE (SAGENT PHARMS INC) APPROVAL= AP YEAR= 2017
NDA 207548 (pdf not found) INN (LEVOLEUCOVORIN CALCIUM) LEVOLEUCOVORIN CALCIUM (AMNEAL) APPROVAL= AP YEAR= 2017
NDA 207241 (pdf not found) INN (LEUCOVORIN CALCIUM) LEUCOVORIN CALCIUM (FRESENIUS KABI USA) APPROVAL= AP YEAR= 2018
NDA 210623 (pdf not found) INN (LEVOLEUCOVORIN CALCIUM) LEVOLEUCOVORIN CALCIUM (NOVAST LABS) APPROVAL= AP YEAR= 2018 DISCONTINUED
NDA 207226 (pdf not found) INN (LEUCOVORIN CALCIUM) LEUCOVORIN CALCIUM (FRESENIUS KABI USA) APPROVAL= AP YEAR= 2018
NDA 210917 (pdf not found) INN (LEUCOVORIN CALCIUM) LEUCOVORIN CALCIUM (INGENUS PHARMS LLC) APPROVAL= AP YEAR= 2018 DISCONTINUED
NDA 210892 (pdf not found) INN (LEVOLEUCOVORIN CALCIUM) LEVOLEUCOVORIN CALCIUM (GLAND) APPROVAL= AP YEAR= 2018
NDA 211226 (label) INN (LEVOLEUCOVORIN) KHAPZORY (ACROTECH BIOPHARMA) APPROVAL= AP YEAR= 2018
NDA 211002 (pdf not found) INN (LEVOLEUCOVORIN CALCIUM) LEVOLEUCOVORIN CALCIUM (MEITHEAL) APPROVAL= AP YEAR= 2019
NDA 211003 (pdf not found) INN (LEVOLEUCOVORIN CALCIUM) LEVOLEUCOVORIN CALCIUM (MEITHEAL) APPROVAL= AP YEAR= 2019 DISCONTINUED
NDA 211132 (pdf not found) INN (LEUCOVORIN CALCIUM) LEUCOVORIN CALCIUM (NOVAST LABS) APPROVAL= AP YEAR= 2020
NDA 213929 (pdf not found) INN (LEUCOVORIN CALCIUM) LEUCOVORIN CALCIUM (LEADING PHARMA LLC) APPROVAL= AP YEAR= 2020
NDA 213797 (pdf not found) INN (LEVOLEUCOVORIN CALCIUM) LEVOLEUCOVORIN CALCIUM (PRAXGEN) APPROVAL= AP YEAR= 2021 DISCONTINUED
NDA 217314 (pdf not found) INN (LEVOLEUCOVORIN CALCIUM) LEVOLEUCOVORIN CALCIUM (HAINAN POLY PHARM) APPROVAL= AP YEAR= 2023
NDA 216590 (pdf not found) INN (LEUCOVORIN CALCIUM) LEUCOVORIN CALCIUM (KINDOS) APPROVAL= AP YEAR= 2023
NDA 217021 (pdf not found) INN (LEUCOVORIN CALCIUM) LEUCOVORIN CALCIUM (HAINAN POLY) APPROVAL= AP YEAR= 2023