e-Drug3D

1848

VALBENAZINE

INN
VALBENAZINE

cas 1025504-45-3

CLASS

NERVOUS SYSTEM
VESICULAR MONOAMINE TRANSPORTER 2 (VMAT2) INHIBITOR (KI = 150 NANOMOLAR)
TREATMENT OF ADULTS WITH TARDIVE DYSKINESIA

ROUTE (list)

ORAL

ATC code

N07XX13

PK parameters

F 49 PERCENT
Tmax 0.75 HOUR
VD 92 LITER
Cl 7.2 LITER / HOUR
PPB 99 PERCENT
t1/2 15 HOUR

Solubility

SLIGHTLY SOLUBLE IN WATER

Target

TARGET VESICULAR MONOAMINE TRANSPORTER 2 (VMAT2)

DrugCentral

Synaptic vesicular amine transporter UNIPROT Q05940 SLC18A2

Download SDF file

L-Valine, (2R,3R,11bR)-1,3,4,6,7,11b-hexahydro-9,10-dimethoxy-3-(2-methylpropyl)-2H-benzo[a]quinolizin-2-yl ester

Formula:
C24H38N2O4

Calculated chemical properties:

MW 418.56
NB_atoms 30
XLogP 3.56
PSA 74.069
NB_HD 2
NB_HA 6
fsp3 0.71
Lipinski(0=no;1=yes) 1

FDA
NDA 209241 (label) INN (VALBENAZINE TOSYLATE) INGREZZA (NEUROCRINE) APPROVAL= AP YEAR= 2017 NEWMOLECULARENTITY
NDA 215962 (pdf not found) INN (VALBENAZINE) VALBENAZINE (SANDOZ INC) APPROVAL= TA YEAR= 2022
NDA 215984 (pdf not found) INN (VALBENAZINE TOSYLATE) VALBENAZINE TOSYLATE (TEVA PHARMS INC) APPROVAL= TA YEAR= 2022
NDA 216137 (pdf not found) INN (VALBENAZINE TOSYLATE) VALBENAZINE TOSYLATE (ZYDUS LIFESCIENCES) APPROVAL= AP YEAR= 2024 DISCONTINUED
NDA 216064 (pdf not found) INN (VALBENAZINE TOSYLATE) VALBENAZINE TOSYLATE (LUPIN LTD) APPROVAL= AP YEAR= 2024
NDA 218390 (label) INN (VALBENAZINE TOSYLATE) INGREZZA SPRINKLE (NEUROCRINE) APPROVAL= AP YEAR= 2024