e-Drug3D

1844

NALDEMEDINE

INN
NALDEMEDINE

cas 916072-89-4

CLASS

METABOLISM
OPIOID ANTAGONIST INDICATED FOR THE TREATMENT OF OPIOID-INDUCED CONSTIPATION (OIC) IN ADULT PATIENTS WITH CHRONIC NON-CANCER PAIN
DERIVATIVE OF NALTREXONE

ROUTE (list)

ORAL

ATC code

A06AH05

PK parameters

Tmax 0.75 HOUR
VD 155 LITER
PPB 93.5 PERCENT
t1/2 11 HOUR

Solubility

SLIGHTLY SOLUBLE IN WATER

Target

TARGET MU OPIOID RECEPTOR
DELTA OPIOID RECEPTOR
KAPPA OPIOID RECEPTOR

DrugCentral

Mu-type opioid receptor UNIPROT P35372 OPRM1

Download SDF file

Morphinan-7-carboxamide, 17-(cyclopropylmethyl)-6,7-didehydro-4,5-epoxy-3,6,14-trihydroxy-N-[1-methyl-1-(3-phenyl-1,2,4-oxadiazol-5-yl)ethyl]-, (5alpha)-

Formula:
C32H34N4O6

Calculated chemical properties:

MW 570.63
NB_atoms 42
XLogP 3.48
PSA 136.762
NB_HD 4
NB_HA 10
fsp3 0.47
Lipinski(0=no;1=yes) 0

FDA
NDA 208854 (pdf not found) INN (NALDEMEDINE TOSYLATE) SYMPROIC (BDSI) APPROVAL= AP YEAR= 2017 NEWMOLECULARENTITY