e-Drug3D

1843

TELOTRISTAT ETHYL

INN
TELOTRISTAT ETHYL

cas 1033805-22-9

CLASS

METABOLISM
TREATMENT OF CARCINOID SYNDROME DIARRHEA
TRYPTOPHAN HYDROXYLASE INHIBITOR WHICH MEDIATES THE RATE LIMITING STEP IN SEROTONIN BIOSYNTHESIS

ROUTE (list)

ORAL

ATC code

A16AX15

PK parameters

Tmax 1.25 HOUR
Cl 2.7 LITER / HOUR
PPB 99 PERCENT
t1/2 0.6 HOUR

Solubility

NEGLIGIBLE AT A PH OF 5 TO 9

Target

TARGET TRYPTOPHAN HYDROXYLASE

Tryptophan 5-hydroxylase 1 UNIPROT P17752 TPH1

Download SDF file

L-Phenylalanine, 4-[2-amino-6-[(1R)-1-[4-chloro-2-(3-methyl-1H-pyrazol-1-yl)phenyl]-2,2,2-trifluoroethoxy]-4-pyrimidinyl]-, ethyl ester

Formula:
C27H26ClF3N6O3

Calculated chemical properties:

MW 574.99
NB_atoms 40
XLogP 4.99
PSA 110.897
NB_HD 4
NB_HA 9
fsp3 0.26
Lipinski(0=no;1=yes) 0

FDA
NDA 208794 (pdf not found) INN (TELOTRISTAT ETIPRATE) XERMELO (TERSERA) APPROVAL= AP YEAR= 2017 NEWMOLECULARENTITY