e-Drug3D

1840

PLECANATIDE

INN
PLECANATIDE

cas 467426-54-6

CLASS

METABOLISM
TREATMENT OF CHRONIC IDIOPATHIC CONSTIPATION (CIC)
GUANYLATE CYCLASE-C AGONIST
STRUCTURALLY RELATED TO HUMAN UROGUANYLIN

ROUTE (list)

ORAL

ATC code

A06AX07

PK parameters

Solubility

SOLUBLE IN WATER

Target

TARGET GUANYLATE CYCLASE-C

DrugCentral

Heat-stable enterotoxin receptor UNIPROT P25092 GUCY2C

Download SDF file

L-Leucine, L-asparaginyl-L-alpha-aspartyl-L-alpha-glutamyl-L-cysteinyl-L-alpha-glutamyl-L-leucyl-L-cysteinyl-L-valyl-L-asparaginyl-L-valyl-L-alanyl-L-cysteinyl-L-threonylglycyl-L-cysteinyl-, cyclic (4->12),(7->15)-bis(disulfide)

Formula:
C65H104N18O26S4

Calculated chemical properties:

MW 1677.91
NB_atoms 113
XLogP -13.49
PSA 653.918
NB_HD 22
NB_HA 44
fsp3 0.68
Lipinski(0=no;1=yes) 0

FDA
NDA 208745 (label) INN (PLECANATIDE) TRULANCE (SALIX) APPROVAL= AP YEAR= 2017 NEWMOLECULARENTITY