e-Drug3D

1839

M DEFLAZACORT

INN
DEFLAZACORT

(is an active metabolite)

cas 13649-57-5

CLASS

HORMONES
CORTICOSTEROID
TREATMENT OF DUCHENNE MUSCULAR DYSTROPHY (DMD)
PRODRUG
ANTI-INFLAMMATORY
IMMUNOSUPPRESSIVE

ROUTE (list)

ATC code

H02AB13

PK parameters

PPB 40 PERCENT

Target

TARGET GLUCOCORTICOID RECEPTOR

PDB
6W9L (STRUCTURE OF THE ANCESTRAL GLUCOCORTICOID RECEPTOR 2 LIGAND BINDING DOMAIN IN COMPLEX WITH DEACETYLATED DEFLAZACORT AND PGC1A COREGULATOR FRAGMENT)

Ligand code = TUS (link to the list of PDB complexes)

Download experimental 3D coordinates of TUS with added hydrogens

DrugCentral

Unknown

Download SDF file

5'H-Pregna-1,4-dieno[17,16-d]oxazole-3,20-dione, 11,21-dihydroxy-2'-methyl-, (11beta,16beta)-

Formula:
C23H29NO5

Calculated chemical properties:

MW 399.47
NB_atoms 29
XLogP 1.99
PSA 85.463
NB_HD 2
NB_HA 6
fsp3 0.70
Lipinski(0=no;1=yes) 1

FDA
-