e-Drug3D

183

PROMAZINE

DISCONTINUED

INN
PROMAZINE

cas 58-40-2

CLASS

NERVOUS SYSTEM
ANTIPSYCHOTIC
ANXIOLYTIC
ANTIEMETICS
DOPAMINE ANTAGONISTS
NEUROLEPTICS
PHENOTHIAZINES

ROUTE (list)

ORAL INJECTION

ATC code

N05AA03

PK parameters

VD 526.5 LITER (65 KILOGRAM)
Cl 54.6 LITER / HOUR (65 KILOGRAM)
PPB 89 PERCENT
t1/2 7.9 HOUR

Target

TARGET DOPAMINE RECEPTOR

PDB
4MA7 (CRYSTAL STRUCTURE OF MOUSE PRION PROTEIN COMPLEXED WITH PROMAZINE)

Ligand code = P2Z (link to the list of PDB complexes)

Download experimental 3D coordinates of P2Z with added hydrogens

DrugCentral

D(2) dopamine receptor UNIPROT P14416 DRD2

5-hydroxytryptamine receptor 2A UNIPROT P28223 HTR2A

Download SDF file

N,N-dimethyl-3-phenothiazin-10-ylpropan-1-amine

Formula:
C17H20N2S

Calculated chemical properties:

MW 284.42
NB_atoms 20
XLogP 4.24
PSA 8.506
NB_HD 0
NB_HA 2
fsp3 0.29
Lipinski(0=no;1=yes) 1

FDA
NDA 084510 (pdf not found) INN (PROMAZINE HYDROCHLORIDE) PROMAZINE HYDROCHLORIDE (WATSON LABS) APPROVAL= - YEAR= 0 DISCONTINUED
NDA 084517 (pdf not found) INN (PROMAZINE HYDROCHLORIDE) PROMAZINE HYDROCHLORIDE (WATSON LABS) APPROVAL= - YEAR= 0 DISCONTINUED
NDA 010349 (pdf not found) INN (PROMAZINE HYDROCHLORIDE) SPARINE (HIKMA) APPROVAL= AP YEAR= 1956 NEWMOLECULARENTITY DISCONTINUED
NDA 010348 (pdf not found) INN (PROMAZINE HYDROCHLORIDE) SPARINE (WYETH AYERST) APPROVAL= AP YEAR= 1957 DISCONTINUED
NDA 010942 (pdf not found) INN (PROMAZINE HYDROCHLORIDE) SPARINE (WYETH AYERST) APPROVAL= AP YEAR= 1957 DISCONTINUED