e-Drug3D

1825

PRASTERONE

INN
PRASTERONE

cas 53-43-0

CLASS

HORMONES
TREATMENT OF MODERATE TO SEVERE DYSPAREUNIA, A SYMPTOM OF VULVAR AND VAGINAL ATROPHY, DUE TO MENOPAUSE
STEROID
IS CONVERTED INTO ACTIVE ANDROGENS AND/OR ESTROGENS

ROUTE (list)

VAGINAL

ATC code

A14AA07
G03XX01
G03EA03

PK parameters

Solubility

INSOLUBLE IN WATER

Target

TARGET HYDROXYSTEROID DEHYDROGENASES
5ALPHA-REDUCTASES
AROMATASES

PDB
1Q22 (CRYSTAL STRUCTURE OF HUMAN CHOLESTEROL SULFOTRANSFERASE (SULT2B1B) IN THE PRESENCE OF DHEA AND PAP)

Ligand code = AND (link to the list of PDB complexes)

Download experimental 3D coordinates of AND with added hydrogens

DrugCentral

Unknown

Download SDF file

Androst-5-en-17-one, 3-hydroxy-, (3beta)-

Formula:
C19H28O2

Calculated chemical properties:

MW 288.41
NB_atoms 21
XLogP 3.88
PSA 39.203
NB_HD 1
NB_HA 2
fsp3 0.84
Lipinski(0=no;1=yes) 1

FDA
NDA 208470 (label) INN (PRASTERONE) INTRAROSA (MILLICENT) APPROVAL= AP YEAR= 2016