e-Drug3D
1824
LIFITEGRAST
INN
LIFITEGRAST
cas 1025967-78-5
CLASS
SENSORY
TREATMENT OF THE SIGNS AND SYMPTOMS OF DRY EYE DISEASE (DED)
LYMPHOCYTE FUNCTION-ASSOCIATED ANTIGEN-1 (LFA-1) ANTAGONIST
LFA-1 IS A CELL SURFACE PROTEIN FOUND ON LEUKOCYTES AND BLOCKS THE INTERACTION OF LFA-1 WITH ITS COGNATE LIGAND INTERCELLULAR ADHESION MOLECULE-1 (ICAM-1)
ROUTE (list)
OPHTHALMIC
ATC code
S01XA25
PK parameters
Solubility
SOLUBLE IN WATER
TARGET LYMPHOCYTE FUNCTION-ASSOCIATED ANTIGEN-1 (LFA-1)
Integrin alpha-L,beta-2 UNIPROT P20701 ITGAL
Formula:
C29H24Cl2N2O7S
Calculated chemical properties:
MW 614.46
NB_atoms 41
XLogP 3.43
PSA 127.262
NB_HD 1
NB_HA 9
fsp3 0.21
Lipinski(0=no;1=yes) 0
NB_atoms 41
XLogP 3.43
PSA 127.262
NB_HD 1
NB_HA 9
fsp3 0.21
Lipinski(0=no;1=yes) 0
FDA
NDA 208073 (label) INN (LIFITEGRAST) XIIDRA (BAUSCH AND LOMB INC) APPROVAL= AP YEAR= 2016
NDA 215063 (label) INN (LIFITEGRAST) LIFITEGRAST (EUGIA PHARMA) APPROVAL= AP YEAR= 2023 DISCONTINUED
NDA 215081 (pdf not found) INN (LIFITEGRAST) LIFITEGRAST (MICRO LABS) APPROVAL= AP YEAR= 2023 DISCONTINUED
NDA 215126 (pdf not found) INN (LIFITEGRAST) LIFITEGRAST (SUN PHARM INDS LTD) APPROVAL= TA YEAR= 2023
NDA 215058 (pdf not found) INN (LIFITEGRAST) LIFITEGRAST (INGENUS PHARMS LLC) APPROVAL= AP YEAR= 2024 DISCONTINUED
NDA 208073 (label) INN (LIFITEGRAST) XIIDRA (BAUSCH AND LOMB INC) APPROVAL= AP YEAR= 2016
NDA 215063 (label) INN (LIFITEGRAST) LIFITEGRAST (EUGIA PHARMA) APPROVAL= AP YEAR= 2023 DISCONTINUED
NDA 215081 (pdf not found) INN (LIFITEGRAST) LIFITEGRAST (MICRO LABS) APPROVAL= AP YEAR= 2023 DISCONTINUED
NDA 215126 (pdf not found) INN (LIFITEGRAST) LIFITEGRAST (SUN PHARM INDS LTD) APPROVAL= TA YEAR= 2023
NDA 215058 (pdf not found) INN (LIFITEGRAST) LIFITEGRAST (INGENUS PHARMS LLC) APPROVAL= AP YEAR= 2024 DISCONTINUED