e-Drug3D

1823

CRISABOROLE

INN
CRISABOROLE

cas 906673-24-3

CLASS

DERMATOLOGICALS
TREATMENT OF MILD TO MODERATE ATOPIC DERMATITIS
PHOSPHODIESTERASE 4 (PDE-4) INHIBITOR

ROUTE (list)

TOPICAL

ATC code

D11AH06

PK parameters

PPB 97 PERCENT

Solubility

INSOLUBLE IN WATER

Target

TARGET PHOSPHODIESTERASE 4

DrugCentral

Phosphodiesterase 4 UNIPROT P27815 PDE4A

Download SDF file

Benzonitrile, 4-[(1,3-dihydro-1-hydroxy-2,1-benzoxaborol-5-yl)oxy]-

Formula:
C14H10BNO3

Calculated chemical properties:

MW 251.04
NB_atoms 19
XLogP 1.57
PSA 62.583
NB_HD 1
NB_HA 4
fsp3 0.07
Lipinski(0=no;1=yes) 1

FDA
NDA 207695 (label) INN (CRISABOROLE) EUCRISA (ANACOR PHARMS INC) APPROVAL= AP YEAR= 2016 NEWMOLECULARENTITY
NDA 216242 (pdf not found) INN (CRISABOROLE) CRISABOROLE (MACLEODS PHARMS LTD) APPROVAL= TA YEAR= 2025