e-Drug3D

1821

IXAZOMIB CITRATE

INN
IXAZOMIB CITRATE

cas 1239908-20-3

CLASS

ANTINEOPLASTIC
TREATMENT OF MULTIPLE MYELOMA
PROTEASOME INHIBITOR
PRODRUG OF IXAZOMIB
CHYMOTRYPSIN-LIKE ACTIVITY OF THE BETA 5 SUBUNIT OF THE 20S PROTEASOME

ROUTE (list)

ORAL

ATC code

L01XG03

PK parameters

Target

TARGET 20S PROTEASOME

DrugCentral

Proteasome subunit beta type-5 UNIPROT P28074 PSMB5

Download SDF file

1,3,2-Dioxaborolane-4,4-diacetic acid, 2-[(1R)-1-[[2-[(2,5-dichlorobenzoyl)amino]acetyl]amino]-3-methylbutyl]-5-oxo-

Formula:
C20H23BCl2N2O9

Calculated chemical properties:

MW 515.10
NB_atoms 34
XLogP -1.13
PSA 151.144
NB_HD 2
NB_HA 11
fsp3 0.45
Lipinski(0=no;1=yes) 0

FDA
NDA 208462 (label) INN (IXAZOMIB CITRATE) NINLARO (TAKEDA PHARMS USA) APPROVAL= AP YEAR= 2015