e-Drug3D

1815

ELBASVIR

INN
ELBASVIR

cas 1370468-36-2

CLASS

ANTIINFECTIVES
HEPATITIS C VIRUS (HCV) NS5A INHIBITOR

ROUTE (list)

ORAL

ATC code

J05AP10
J05AP54

PK parameters

Tmax 3 HOUR
VD 680 LITER
PPB 99.9 PERCENT
t1/2 24 HOUR

Solubility

PRACTICALLY INSOLUBLE IN WATER

Target

TARGET NS5A

DrugCentral

Genome polyprotein UNIPROT P26663

Genome polyprotein UNIPROT P27958

Download SDF file

Carbamic acid, N,N'-[[(6S)-6-phenyl-6H-indolo[1,2-c][1,3]benzoxazine-3,10-diyl]bis[1H-imidazole-5,2-diyl-(2S)-2,1-pyrrolidinediyl[(1S)-1-(1-methylethyl)-2-oxo-2,1-ethanediyl]]]bis-, C,C'-dimethyl ester

Formula:
C49H55N9O7

Calculated chemical properties:

MW 882.02
NB_atoms 65
XLogP 8.12
PSA 166.204
NB_HD 4
NB_HA 16
fsp3 0.39
Lipinski(0=no;1=yes) 0

FDA
NDA 208261 (pdf not found) INN (ELBASVIR ; GRAZOPREVIR) ZEPATIER (MSD SUB MERCK) APPROVAL= AP YEAR= 2016