e-Drug3D

1806

SELEXIPAG

INN
SELEXIPAG

(has an active metabolite)

cas 475086-01-2

CLASS

BLOOD
SELECTIVE NON-PROSTANOID IP PROSTACYCLIN RECEPTOR AGONIST
TREATMENT OF PULMONARY ARTERIAL HYPERTENSION (PAH)

ROUTE (list)

ORAL INTRAVENOUS

ATC code

B01AC27

PK parameters

Tmax 2 HOUR
Cl 35 LITER / HOUR
PPB 99 PERCENT
t1/2 1.65 HOUR

Solubility

PRACTICALLY INSOLUBLE IN WATER

Target

TARGET IP PROSTACYCLIN RECEPTOR

DrugCentral

Prostacyclin receptor UNIPROT P43119 PTGIR

Download SDF file

Acetamide, 2-[4-[(5,6-diphenyl-2-pyrazinyl)(1-methylethyl)amino]butoxy]-N-(methylsulfonyl)-

Formula:
C26H32N4O4S

Calculated chemical properties:

MW 496.63
NB_atoms 35
XLogP 3.90
PSA 94.582
NB_HD 1
NB_HA 8
fsp3 0.35
Lipinski(0=no;1=yes) 1

FDA
NDA 207947 (label) INN (SELEXIPAG) UPTRAVI (ACTELION) APPROVAL= AP YEAR= 2015 NEWMOLECULARENTITY
NDA 214367 (pdf not found) INN (SELEXIPAG) SELEXIPAG (MSN LABORATORIES PRIVATE LTD) APPROVAL= TA YEAR= 2021
NDA 214275 (label) INN (SELEXIPAG) UPTRAVI (ACTELION) APPROVAL= AP YEAR= 2021
NDA 214302 (pdf not found) INN (SELEXIPAG) SELEXIPAG (ZYDUS LIFESCIENCES) APPROVAL= AP YEAR= 2022 DISCONTINUED
NDA 214055 (pdf not found) INN (SELEXIPAG) SELEXIPAG (VGYAAN) APPROVAL= TA YEAR= 2023
NDA 214414 (pdf not found) INN (SELEXIPAG) SELEXIPAG (ALEMBIC) APPROVAL= AP YEAR= 2023