e-Drug3D

1789

cas 149709-62-6

CLASS

CARDIOVASCULAR
NEUTRAL ENDOPEPTIDASE NEPRILYSIN (NEP) INHIBITOR
TREATMENT OF PATIENTS WITH CHRONIC HEART FAILURE

ROUTE (list)

ORAL

PK parameters

F 60 PERCENT
Tmax 0.5 HOUR
VD 103 LITER
Cl 51 LITER / HOUR (EQN)
PPB 94 PERCENT
t1/2 1.4 HOUR

MW 410.47
NB_atoms 30
XLogP 2.50
PSA 83.427
NB_HD 1
NB_HA 6
fsp3 0.38
Lipinski(0=no;1=yes) 1

FDA
NDA 207620 (pdf not found) INN (SACUBITRIL ; VALSARTAN) ENTRESTO (NOVARTIS PHARMS CORP) APPROVAL= AP YEAR= 2015
NDA 213605 (pdf not found) INN (SACUBITRIL ; VALSARTAN) SACUBITRIL AND VALSARTAN (CRYSTAL) APPROVAL= AP YEAR= 2024
NDA 213676 (pdf not found) INN (SACUBITRIL ; VALSARTAN) SACUBITRIL AND VALSARTAN (LAURUS) APPROVAL= AP YEAR= 2024
NDA 213682 (pdf not found) INN (SACUBITRIL ; VALSARTAN) SACUBITRIL AND VALSARTAN (ALEMBIC) APPROVAL= AP YEAR= 2024
NDA 218591 (pdf not found) INN (SACUBITRIL ; VALSARTAN) ENTRESTO SPRINKLE (NOVARTIS) APPROVAL= AP YEAR= 2024
NDA 213604 (pdf not found) INN (SACUBITRIL ; VALSARTAN) SACUBITRIL AND VALSARTAN (TORRENT) APPROVAL= AP YEAR= 2024
NDA 213680 (pdf not found) INN (SACUBITRIL ; VALSARTAN) SACUBITRIL AND VALSARTAN (BIOCON PHARMA) APPROVAL= AP YEAR= 2024
NDA 213719 (pdf not found) INN (SACUBITRIL ; VALSARTAN) SACUBITRIL AND VALSARTAN (ZYDUS PHARMS) APPROVAL= AP YEAR= 2024
NDA 213728 (pdf not found) INN (SACUBITRIL ; VALSARTAN) SACUBITRIL AND VALSARTAN (MACLEODS PHARMS LTD) APPROVAL= AP YEAR= 2024
NDA 213764 (pdf not found) INN (SACUBITRIL ; VALSARTAN) SACUBITRIL AND VALSARTAN (ALKEM LABS LTD) APPROVAL= AP YEAR= 2024
NDA 213611 (pdf not found) INN (SACUBITRIL ; VALSARTAN) SACUBITRIL AND VALSARTAN (NOVUGEN PHARMA SDN) APPROVAL= AP YEAR= 2025
NDA 213627 (pdf not found) INN (SACUBITRIL ; VALSARTAN) SACUBITRIL AND VALSARTAN (DR REDDYS) APPROVAL= AP YEAR= 2025
NDA 213668 (pdf not found) INN (SACUBITRIL ; VALSARTAN) SACUBITRIL AND VALSARTAN (HETERO LABS LTD III) APPROVAL= AP YEAR= 2025
NDA 213748 (pdf not found) INN (SACUBITRIL ; VALSARTAN) SACUBITRIL AND VALSARTAN (MSN) APPROVAL= AP YEAR= 2025
NDA 213808 (pdf not found) INN (SACUBITRIL ; VALSARTAN) SACUBITRIL AND VALSARTAN (LUPIN) APPROVAL= AP YEAR= 2025