e-Drug3D

1787

ISAVUCONAZONIUM

INN
ISAVUCONAZONIUM

(has an active metabolite)

cas 742049-41-8

CLASS

ANTIINFECTIVES
AN AZOLE ANTIFUNGAL
TREATMENT OF INVASIVE ASPERGILLOSIS AND MUCORMYCOSIS

ROUTE (list)

ORAL INTRAVENOUS

ATC code

J02AC05

PK parameters

Target

TARGET LANOSTEROL 14 ALPHA-DEMETHYLASE (CYTOCHROME P450 P-45014DM PMID26598096)

DrugCentral

Unknown

Download SDF file

Glycine, N-methyl-, [2-[[[1-[1-[(2R,3R)-3-[4-(4-cyanophenyl)-2-thiazolyl]-2-(2,5-difluorophenyl)-2-hydroxybutyl]-1H-1,2,4-triazolium-4-yl]ethoxy]carbonyl]methylamino]-3-pyridinyl]methyl ester (9CI)

Formula:
C35H35F2N8O5S

Calculated chemical properties:

MW 717.78
NB_atoms 51
XLogP 4.58
PSA 135.686
NB_HD 2
NB_HA 12
fsp3 0.29
Lipinski(0=no;1=yes) 0

FDA
NDA 207500 (label) INN (ISAVUCONAZONIUM SULFATE) CRESEMBA (ASTELLAS) APPROVAL= AP YEAR= 2015 NEWMOLECULARENTITY
NDA 207501 (label) INN (ISAVUCONAZONIUM SULFATE) CRESEMBA (ASTELLAS) APPROVAL= AP YEAR= 2015