e-Drug3D

1786

ELUXADOLINE

INN
ELUXADOLINE

cas 864821-90-9

CLASS

NERVOUS SYSTEM
TREATMENT OF IRRITABLE BOWEL SYNDROME WITH DIARRHEA (IBS-D)
MU-OPIOID RECEPTOR AGONIST (KI = 1.8 NANOMOLAR)
DELTA-OPIOID RECEPTOR ANTAGONIST (KI = 430 NANOMOLAR)
KAPPA-OPIOID RECEPTOR AGONIST

ROUTE (list)

ORAL

ATC code

A07DA06

PK parameters

Tmax 1.5 HOUR
PPB 81 PERCENT
t1/2 4.8 HOUR

Target

TARGET MU-OPIOID RECEPTOR

DrugCentral

Mu-type opioid receptor UNIPROT P35372 OPRM1

Delta-type opioid receptor UNIPROT P41143 OPRD1

Download SDF file

Benzoic acid, 5-[[[(2S)-2-amino-3-[4-(aminocarbonyl)-2,6-dimethylphenyl]-1-oxopropyl][(1S)-1-(5-phenyl-1H-imidazol-2-yl)ethyl]amino]methyl]-2-methoxy-

Formula:
C32H35N5O5

Calculated chemical properties:

MW 568.64
NB_atoms 42
XLogP 2.82
PSA 142.632
NB_HD 5
NB_HA 10
fsp3 0.25
Lipinski(0=no;1=yes) 0

FDA
NDA 206940 (pdf not found) INN (ELUXADOLINE) VIBERZI (ABBVIE) APPROVAL= AP YEAR= 2015
NDA 213576 (pdf not found) INN (ELUXADOLINE) ELUXADOLINE (MSN PHARMACEUTICALS INC) APPROVAL= TA YEAR= 2021
NDA 213613 (pdf not found) INN (ELUXADOLINE) ELUXADOLINE (ASCEND LABORATORIES, LTD) APPROVAL= TA YEAR= 2021
NDA 213522 (pdf not found) INN (ELUXADOLINE) ELUXADOLINE (ZYDUS PHARMS) APPROVAL= AP YEAR= 2025