e-Drug3D

1783

IVABRADINE

INN
IVABRADINE

cas 155974-00-8

CLASS

CARDIOVASCULAR
HYPERPOLARIZATION-ACTIVATED CYCLIC NUCLEOTIDE-GATED CHANNEL BLOCKER

ROUTE (list)

ORAL

ATC code

C07FX06
C01EB17
C07FX05

PK parameters

F 40 PERCENT
Tmax 1 HOUR
VD 100 LITER
Cl 24 LITER / HOUR
PPB 70 PERCENT
t1/2 6 HOUR

Target

TARGET HYPERPOLARIZATION-ACTIVATED CYCLIC NUCLEOTIDE-GATED (HCN) CHANNEL

PDB
8OFI (IVABRADINE BOUND TO HCN4 CHANNEL)

Ligand code = VNZ (link to the list of PDB complexes)

Download experimental 3D coordinates of VNZ with added hydrogens

DrugCentral

Potassium,sodium hyperpolarization-activated cyclic nucleotide-gated channel 1 UNIPROT O60741 HCN1

Potassium,sodium hyperpolarization-activated cyclic nucleotide-gated channel 2 UNIPROT Q9UL51 HCN2

Download SDF file

2H-3-Benzazepin-2-one, 3-[3-[[[(7S)-3,4-dimethoxybicyclo[4.2.0]octa-1,3,5-trien-7-yl]methyl]methylamino]propyl]-1,3,4,5-tetrahydro-7,8-dimethoxy-

Formula:
C27H36N2O5

Calculated chemical properties:

MW 468.58
NB_atoms 34
XLogP 3.31
PSA 67.773
NB_HD 0
NB_HA 7
fsp3 0.52
Lipinski(0=no;1=yes) 1

FDA
NDA 206143 (pdf not found) INN (IVABRADINE HYDROCHLORIDE) CORLANOR (AMGEN INC) APPROVAL= AP YEAR= 2015 NEWMOLECULARENTITY
NDA 209964 (pdf not found) INN (IVABRADINE) CORLANOR (AMGEN INC) APPROVAL= AP YEAR= 2019
NDA 214051 (pdf not found) INN (IVABRADINE HYDROCHLORIDE) IVABRADINE HYDROCHLORIDE (INGENUS PHARMS LLC) APPROVAL= AP YEAR= 2021
NDA 213366 (pdf not found) INN (IVABRADINE HYDROCHLORIDE) IVABRADINE HYDROCHLORIDE (ANNORA PHARMA) APPROVAL= AP YEAR= 2022
NDA 213442 (pdf not found) INN (IVABRADINE HYDROCHLORIDE) IVABRADINE HYDROCHLORIDE (ZYDUS PHARMS) APPROVAL= AP YEAR= 2023
NDA 215238 (pdf not found) INN (IVABRADINE HYDROCHLORIDE) IVABRADINE HYDROCHLORIDE (ALEMBIC) APPROVAL= AP YEAR= 2024
NDA 213276 (pdf not found) INN (IVABRADINE HYDROCHLORIDE) IVABRADINE HYDROCHLORIDE (BIONPHARMA) APPROVAL= AP YEAR= 2024
NDA 213483 (pdf not found) INN (IVABRADINE HYDROCHLORIDE) IVABRADINE HYDROCHLORIDE (MSN) APPROVAL= AP YEAR= 2025