e-Drug3D

1779

SONIDEGIB

INN
SONIDEGIB

cas 956697-53-3

CLASS

ANTINEOPLASTIC
SMOOTHENED (SMO) ANTAGONIST WHICH INHIBITS THE HEDGEHOG (HH) SIGNALING PATHWAY

ROUTE (list)

ORAL

ATC code

L01XJ02

PK parameters

F 10 PERCENT
Tmax 3 HOUR
VD 9166 LITER
Cl 9.4 LITER / HOUR (EQN)
PPB 97 PERCENT
t1/2 672 HOUR

Solubility

INSOLUBLE IN WATER

Target

TARGET SMOOTHENED (SMO)

Smoothened homolog UNIPROT Q99835 SMO

Download SDF file

[1,1'-Biphenyl]-3-carboxamide, N-[6-[(2R,6S)-2,6-dimethyl-4-morpholinyl]-3-pyridinyl]-2-methyl-4'-(trifluoromethoxy)-, rel-

Formula:
C26H26F3N3O3

Calculated chemical properties:

MW 485.50
NB_atoms 35
XLogP 5.82
PSA 58.031
NB_HD 1
NB_HA 6
fsp3 0.31
Lipinski(0=no;1=yes) 0

FDA
NDA 205266 (pdf not found) INN (SONIDEGIB PHOSPHATE) ODOMZO (SUN PHARM) APPROVAL= AP YEAR= 2015 NEWMOLECULARENTITY