e-Drug3D

1771

CORTISONE

INN
CORTISONE

cas 53-06-5

CLASS

METABOLISM
GLUCOCORTICOID
ANTIINFLAMMATORY
VASOCONSTRICTOR
REPLACEMENT THERAPY IN ADRENOCORTICAL DEFICIENCY STATES
PSORIATIC ARTHRITIS RHEUMATOID ARTHRITIS

ROUTE (list)

ATC code

H02AB10
S01BA03

PK parameters

Target

TARGET GLUCOCORTICOID RECEPTOR

PDB
8CC0 (CRYSTAL STRUCTURE OF ANTI-CORTISOL FAB IN COMPLEX WITH CORTISONE)

Ligand code = UQC (link to the list of PDB complexes)

Download experimental 3D coordinates of UQC with added hydrogens

DrugCentral

Glucocorticoid receptor UNIPROT P04150 NR3C1

Download SDF file

Pregn-4-ene-3,11,20-trione, 17,21-dihydroxy-

Formula:
C21H28O5

Calculated chemical properties:

MW 360.43
NB_atoms 26
XLogP 1.99
PSA 85.907
NB_HD 2
NB_HA 5
fsp3 0.76
Lipinski(0=no;1=yes) 1

FDA
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