e-Drug3D

177

HYDROXYAMPHETAMINE

DISCONTINUED

INN
HYDROXYAMPHETAMINE

cas 103-86-6

CLASS

NERVOUS SYSTEM
SYMPATHOMIMETICS
CAUSES THE RELEASE OF ENDOGENOUS NOREPINEPHRINE
MYDRIATIC EFFECT
PROVIDES DIMINISHED PUPIL RESPONSIVENESS TO LIGHT
ADRENERGIC AGENT

ROUTE (list)

OPHTHALMIC

ATC code

N06BA01

PK parameters

Target

TARGET MONOAMINE TRANSPORTER

PDB
3BUF (BACE-1 COMPLEXED WITH COMPOUND 2)

Ligand code = AEG (link to the list of PDB complexes)

Download experimental 3D coordinates of AEG with added hydrogens

DrugCentral

Sodium-dependent noradrenaline transporter UNIPROT P23975 SLC6A2

Sodium-dependent dopamine transporter UNIPROT Q01959 SLC6A3

Download SDF file

Phenol, 4-(2-aminopropyl)-

Formula:
C9H13NO

Calculated chemical properties:

MW 151.20
NB_atoms 11
XLogP 1.28
PSA 45.902
NB_HD 3
NB_HA 2
fsp3 0.33
Lipinski(0=no;1=yes) 1

FDA
NDA 000004 (pdf not found) INN (HYDROXYAMPHETAMINE HYDROBROMIDE) PAREDRINE (PHARMICS) APPROVAL= AP YEAR= 1969 DISCONTINUED
NDA 019261 (label) INN (HYDROXYAMPHETAMINE HYDROBROMIDE ; TROPICAMIDE) PAREMYD (EPIC PHARMA LLC) APPROVAL= AP YEAR= 1992 DISCONTINUED