e-Drug3D

1759

M THIOGUANINE

INN
THIOGUANINE

cas 15867-02-4

CLASS

ANTINEOPLASTIC
ANTIMETABOLITES
TREATMENT OF ACUTE NONLYMPHOCYTIC LEUKEMIAS
THIOGUANINE IS INCORPORATED INTO THE DNA AND THE RNA OF HUMAN BONE MARROW CELLS
THIOGUANYLIC ACID IS FURTHER CONVERTED TO THE DI- AND TRI-PHOSPHATES

ROUTE (list)

ATC code

L01BB03

PK parameters

Target

TARGET IMP DEHYDROGENASE
GLUTAMINE-5-PHOSPHORIBOSYLPYROPHOSPHATE AMIDOTRANSFERASE

DrugCentral

Inosine-5-monophosphate dehydrogenase 1 UNIPROT P20839 IMPDH1

Inosine-5-monophosphate dehydrogenase 2 UNIPROT P12268 IMPDH2

Download SDF file

5'-Guanylic acid, 6-thio-

Formula:
C10H14N5O7PS

Calculated chemical properties:

MW 377.29
NB_atoms 24
XLogP -2.46
PSA 179.38
NB_HD 5
NB_HA 12
fsp3 0.50
Lipinski(0=no;1=yes) 0

FDA
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