e-Drug3D

1753

CLOMIPHENE

INN
CLOMIPHENE

cas 911-45-5

CLASS

GENITO
INITIATION OF OVULATION
FERTILITY AGENTS, FEMALE
ESTROGEN RECEPTOR ANTAGONIST
ZUCLOMIPHENE (CIS) HAS A LONGER HALF-LIFE THAN ENCLOMIPHENE (TRANS)

ROUTE (list)

ORAL

ATC code

G03GB02

PK parameters

Solubility

SLIGHTLY SOLUBLE IN WATER

Target

TARGET ESTROGEN RECEPTOR

PDB
6VPF (ESTROGEN RECEPTOR ALPHA LIGAND BINDING DOMAIN IN COMPLEX WITH THE SELECTIVE ESTROGEN RECEPTOR MODULATOR CLOMIPHENE)

Ligand code = 53Q (link to the list of PDB complexes)

Download experimental 3D coordinates of 53Q with added hydrogens

DrugCentral

Estrogen receptor UNIPROT P03372 ESR1

Download SDF file

2-[4-[(Z)-2-chloro-1,2-di(phenyl)ethenyl]phenoxy]-N,N-diethylethanamine

Formula:
C26H28ClNO

Calculated chemical properties:

MW 405.94
NB_atoms 29
XLogP 6.56
PSA 13.765
NB_HD 0
NB_HA 2
fsp3 0.23
Lipinski(0=no;1=yes) 0

FDA
NDA 016131 (pdf not found) INN (CLOMIPHENE CITRATE) CLOMID (SANOFI AVENTIS US) APPROVAL= AP YEAR= 1967 DISCONTINUED
NDA 018361 (pdf not found) INN (CLOMIPHENE CITRATE) SEROPHENE (EMD SERONO) APPROVAL= AP YEAR= 1982 DISCONTINUED
NDA 072196 (pdf not found) INN (CLOMIPHENE CITRATE) MILOPHENE (GRANATA BIO) APPROVAL= AP YEAR= 1988 DISCONTINUED
NDA 075528 (pdf not found) INN (CLOMIPHENE CITRATE) CLOMIPHENE CITRATE (COSETTE) APPROVAL= AP YEAR= 1999
NDA 216545 (pdf not found) INN (CLOMIPHENE CITRATE) CLOMIPHENE CITRATE (RUBICON) APPROVAL= AP YEAR= 2024
NDA 216739 (pdf not found) INN (CLOMIPHENE CITRATE) CLOMIPHENE CITRATE (APPCO) APPROVAL= AP YEAR= 2024