e-Drug3D

1743

AVIBACTAM

INN
AVIBACTAM

cas 1192500-31-4

CLASS

ANTIINFECTIVES
CLASS D (OR OXA-TYPE) BETA-LACTAMASES INHIBITOR

ROUTE (list)

INTRAVENOUS

ATC code

PK parameters

VD 23.2 LITER
Cl 11.9 LITER / HOUR
PPB 6.9 PERCENT
t1/2 2.22 HOUR

Target

TARGET BETA LACTAMASE

PDB
4S2N (OXA-48)

Ligand code = FYG (link to the list of PDB complexes)

Download experimental 3D coordinates of FYG with added hydrogens

DrugCentral

Beta-lactamase UNIPROT P05364 ampC

Beta-lactamase UNIPROT P24735 ampC

Download SDF file

Sulfuric acid, mono[(1R,2S,5R)-2-(aminocarbonyl)-7-oxo-1,6-diazabicyclo[3.2.1]oct-6-yl] ester

Formula:
C7H11N3O6S

Calculated chemical properties:

MW 265.26
NB_atoms 17
XLogP -1.53
PSA 127.931
NB_HD 3
NB_HA 9
fsp3 0.71
Lipinski(0=no;1=yes) 1

FDA
NDA 206494 (label) INN (AVIBACTAM SODIUM ; CEFTAZIDIME) AVYCAZ (ALLERGAN) APPROVAL= AP YEAR= 2015
NDA 217906 (label) INN (AVIBACTAM SODIUM ; AZTREONAM) EMBLAVEO (ABBVIE) APPROVAL= AP YEAR= 2025