e-Drug3D
1736
TASIMELTEON
INN
TASIMELTEON
cas 609799-22-6
CLASS
NERVOUS SYSTEM
MELATONIN RECEPTOR AGONIST
NON-24-HOURSLEEP-WAKE DISORDER (NON-24)
CONTROL OF CIRCADIAN RHYTHMS
ROUTE (list)
ORAL
ATC code
N05CH03
PK parameters
F 38.3 PERCENT
Tmax 1.75 HOUR
VD 92.5 LITER
Cl 49.3 LITER / HOUR (EQN)
PPB 90 PERCENT
t1/2 1.3 HOUR
Solubility
SLIGHTLY SOLUBLE IN WATER
TARGET MELATONIN MT1 RECEPTOR
MELATONIN MT2 RECEPTOR
Melatonin receptor type 1A UNIPROT P48039 MTNR1A
Melatonin receptor type 1B UNIPROT P49286 MTNR1B
Formula:
C15H19NO2
Calculated chemical properties:
MW 245.31
NB_atoms 18
XLogP 2.25
PSA 39.957
NB_HD 1
NB_HA 3
fsp3 0.53
Lipinski(0=no;1=yes) 1
NB_atoms 18
XLogP 2.25
PSA 39.957
NB_HD 1
NB_HA 3
fsp3 0.53
Lipinski(0=no;1=yes) 1
FDA
NDA 205677 (label) INN (TASIMELTEON) HETLIOZ (VANDA PHARMS INC) APPROVAL= AP YEAR= 2014 NEWMOLECULARENTITY
NDA 214517 (label) INN (TASIMELTEON) HETLIOZ LQ (VANDA PHARMS INC) APPROVAL= AP YEAR= 2020
NDA 211601 (pdf not found) INN (TASIMELTEON) TASIMELTEON (TEVA PHARMS USA INC) APPROVAL= AP YEAR= 2022
NDA 211607 (pdf not found) INN (TASIMELTEON) TASIMELTEON (APOTEX) APPROVAL= AP YEAR= 2022
NDA 211654 (pdf not found) INN (TASIMELTEON) TASIMELTEON (MSN) APPROVAL= AP YEAR= 2023
NDA 205677 (label) INN (TASIMELTEON) HETLIOZ (VANDA PHARMS INC) APPROVAL= AP YEAR= 2014 NEWMOLECULARENTITY
NDA 214517 (label) INN (TASIMELTEON) HETLIOZ LQ (VANDA PHARMS INC) APPROVAL= AP YEAR= 2020
NDA 211601 (pdf not found) INN (TASIMELTEON) TASIMELTEON (TEVA PHARMS USA INC) APPROVAL= AP YEAR= 2022
NDA 211607 (pdf not found) INN (TASIMELTEON) TASIMELTEON (APOTEX) APPROVAL= AP YEAR= 2022
NDA 211654 (pdf not found) INN (TASIMELTEON) TASIMELTEON (MSN) APPROVAL= AP YEAR= 2023