e-Drug3D

1735

DASABUVIR

DISCONTINUED

INN
DASABUVIR

cas 1132935-63-7

CLASS

ANTIINFECTIVES
TREATMENT OF GENOTYPE 1 CHRONIC HEPATITIS C VIRUS (HCV)
HEPATITIS C VIRUS NON-NUCLEOSIDE NS5B PALM POLYMERASE INHIBITOR

ROUTE (list)

ORAL

ATC code

J05AP09
J05AP52

PK parameters

F 70 PERCENT
Tmax 4.5 HOUR
VD 396 LITER
Cl 47.7 LITER / HOUR (EQN)
PPB 99.5 PERCENT
t1/2 5.75 HOUR

Solubility

SLIGHTLY SOLUBLE IN WATER

Target

TARGET HCV NON-NUCLEOSIDE NS5B PALM POLYMERASE

DrugCentral

Unknown

Download SDF file

Methanesulfonamide, N-[6-[5-(3,4-dihydro-2,4-dioxo-1(2H)-pyrimidinyl)-3-(1,1-dimethylethyl)-2-methoxyphenyl]-2-naphthalenyl]-

Formula:
C26H27N3O5S

Calculated chemical properties:

MW 493.58
NB_atoms 35
XLogP 4.02
PSA 104.666
NB_HD 2
NB_HA 8
fsp3 0.23
Lipinski(0=no;1=yes) 1

FDA
NDA 206619 (label) INN (DASABUVIR SODIUM ; OMBITASVIR ; PARITAPREVIR ; RITONAVIR) VIEKIRA PAK COPACKAGED (ABBVIE) APPROVAL= AP YEAR= 2014 DISCONTINUED
NDA 208624 (label) INN (DASABUVIR SODIUM ; OMBITASVIR ; PARITAPREVIR ; RITONAVIR) VIEKIRA XR (ABBVIE) APPROVAL= AP YEAR= 2016 DISCONTINUED