e-Drug3D

1733

OMBITASVIR

DISCONTINUED

INN
OMBITASVIR

cas 1258226-87-7

CLASS

ANTIINFECTIVES
TREATMENT OF GENOTYPE 1 CHRONIC HEPATITIS C VIRUS (HCV)
HEPATITIS C VIRUS NS5A INHIBITOR

ROUTE (list)

ORAL

ATC code

J05AP53

PK parameters

F 48.1 PERCENT
Tmax 4.5 HOUR
VD 50.1 LITER
Cl 1.5 LITER / HOUR (EQN)
PPB 99.9 PERCENT
t1/2 23 HOUR

Solubility

PRACTICALLY INSOLUBLE IN AQUEOUS BUFFERS

Target

TARGET HCV NS5A

DrugCentral

Genome polyprotein UNIPROT P26663

Genome polyprotein UNIPROT P27958

Download SDF file

L-Prolinamide, 2,2'-[[(2S,5S)-1-[4-(1,1-dimethylethyl)phenyl]-2,5-pyrrolidinediyl]di-4,1-phenylene]bis[N-(methoxycarbonyl)-L-valyl-

Formula:
C50H67N7O8

Calculated chemical properties:

MW 894.11
NB_atoms 65
XLogP 7.69
PSA 160.166
NB_HD 4
NB_HA 15
fsp3 0.52
Lipinski(0=no;1=yes) 0

FDA
NDA 206619 (pdf not found) INN (DASABUVIR SODIUM ; OMBITASVIR ; PARITAPREVIR ; RITONAVIR) VIEKIRA PAK COPACKAGED (ABBVIE) APPROVAL= AP YEAR= 2014 DISCONTINUED
NDA 207931 (pdf not found) INN (OMBITASVIR ; PARITAPREVIR ; RITONAVIR) TECHNIVIE (ABBVIE) APPROVAL= AP YEAR= 2015 DISCONTINUED
NDA 208624 (pdf not found) INN (DASABUVIR SODIUM ; OMBITASVIR ; PARITAPREVIR ; RITONAVIR) VIEKIRA XR (ABBVIE) APPROVAL= AP YEAR= 2016 DISCONTINUED