e-Drug3D
1729
BELINOSTAT
INN
BELINOSTAT
cas 414864-00-9
CLASS
ANTINEOPLASTIC
HISTONE DEACETYLASE (HDAC) INHIBITOR
TREATMENT OF T-CELL LYMPHOMA (PTCL)
ROUTE (list)
INTRAVENOUS
ATC code
L01XH04
PK parameters
VD 40 LITER
Cl 74.4 LITER / HOUR
PPB 94.3 PERCENT
t1/2 1.1 HOUR
Solubility
SLIGHTLY SOLUBLE IN DISTILLED WATER (0.14 MILLIGRAM / MILLILITER)
TARGET HISTONE DEACETYLASE (HDAC)
PDB
5EEN (CRYSTAL STRUCTURE OF DANIO RERIO HISTONE DEACETYLASE 6 CATALYTIC DOMAIN 2 IN COMPLEX WITH BELINOSTAT)
Ligand code = 5OG (link to the list of PDB complexes)
Download experimental 3D coordinates of 5OG with added hydrogens
Histone deacetylase 5 UNIPROT Q9UQL6 HDAC5
Histone deacetylase 2 UNIPROT Q92769 HDAC2
Formula:
C15H14N2O4S
Calculated chemical properties:
MW 318.35
NB_atoms 22
XLogP 2.01
PSA 99.313
NB_HD 3
NB_HA 6
fsp3 0.00
Lipinski(0=no;1=yes) 1
NB_atoms 22
XLogP 2.01
PSA 99.313
NB_HD 3
NB_HA 6
fsp3 0.00
Lipinski(0=no;1=yes) 1
FDA
NDA 206256 (pdf not found) INN (BELINOSTAT) BELEODAQ (ACROTECH BIOPHARMA) APPROVAL= AP YEAR= 2014 NEWMOLECULARENTITY
NDA 206256 (pdf not found) INN (BELINOSTAT) BELEODAQ (ACROTECH BIOPHARMA) APPROVAL= AP YEAR= 2014 NEWMOLECULARENTITY