e-Drug3D

1727

NALOXEGOL

INN
NALOXEGOL

cas 854601-70-0

CLASS

METABOLISM
OPIOID ANTAGONIST
TREATMENT OF OPIOID-INDUCED CONSTIPATION
PEGYLATED DERIVATIVE OF NALOXONE
CNS PENETRATION OF NALOXEGOL IS EXPECTED TO BE NEGLIGIBLE

ROUTE (list)

ORAL

ATC code

A06AH03

PK parameters

Tmax 2 HOUR
VD 1554 LITER
Cl 126 LITER / HOUR (EQN)
PPB 4.2 PERCENT
t1/2 8.5 HOUR

Solubility

HIGH AQUEOUS SOLUBILITY ACROSS THE PHYSIOLOGIC PH RANGE

Target

TARGET MU-OPIOID RECEPTOR

DrugCentral

Mu-type opioid receptor UNIPROT P35372 OPRM1

Download SDF file

Morphinan-3,14-diol, 4,5-epoxy-6-(3,6,9,12,15,18,21-heptaoxadocos-1-yloxy)-17-(2-propen-1-yl)-, (5alpha,6alpha)-

Formula:
C34H53NO11

Calculated chemical properties:

MW 651.77
NB_atoms 46
XLogP 1.86
PSA 139.448
NB_HD 2
NB_HA 12
fsp3 0.76
Lipinski(0=no;1=yes) 0

FDA
NDA 204760 (label) INN (NALOXEGOL OXALATE) MOVANTIK (VALINOR) APPROVAL= AP YEAR= 2014 NEWMOLECULARENTITY
NDA 212625 (pdf not found) INN (NALOXEGOL) NALOXEGOL (MSN LABS PVT LTD) APPROVAL= TA YEAR= 2021