e-Drug3D

1723

PERAMIVIR

INN
PERAMIVIR

cas 330600-85-6

CLASS

ANTIINFECTIVES
INFLUENZA VIRUS NEURAMINIDASE INHIBITOR

ROUTE (list)

INTRAVENOUS

ATC code

J05AH03

PK parameters

Tmax 0.5 HOUR
VD 12.5 LITER
Cl 0.43 LITER / HOUR (EQN)
PPB 30 PERCENT
t1/2 20 HOUR

Target

TARGET NEURAMINIDASE

PDB
3K39 (CRYSTAL STRUCTURE OF B, PERTH NEURAMINIDASE D197E MUTANT IN COMPLEX WITH PERAMIVIR)

Download experimental 3D coordinates of BCZ with added hydrogens

Neuraminidase UNIPROT P03468

Neuraminidase UNIPROT P03474

Download SDF file

Cyclopentanecarboxylic acid, 3-[(1S)-1-(acetylamino)-2-ethylbutyl]-4-[(aminoiminomethyl)amino]-2-hydroxy-, (1S,2S,3R,4R)-

Formula:
C15H28N4O4

Calculated chemical properties:

MW 328.41
NB_atoms 23
XLogP -3.29
PSA 129.225
NB_HD 7
NB_HA 7
fsp3 0.80
Lipinski(0=no;1=yes) 0

FDA
NDA 206426 (label) INN (PERAMIVIR) RAPIVAB (BIOCRYST) APPROVAL= AP YEAR= 2014 NEWMOLECULARENTITY